ID A0A3B4F990_9CICH Unreviewed; 1630 AA.
AC A0A3B4F990;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Kinase D-interacting substrate of 220 kDa {ECO:0000313|Ensembl:ENSPNYP00000006254.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000006254.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000006254.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 303518.ENSPNYP00000006254; -.
DR Ensembl; ENSPNYT00000006413.1; ENSPNYP00000006254.1; ENSPNYG00000004758.1.
DR GeneTree; ENSGT00940000156714; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011646; KAP_P-loop.
DR PANTHER; PTHR24116; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR PANTHER; PTHR24116:SF2; KINASE D-INTERACTING SUBSTRATE OF 220 KDA B; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07693; KAP_NTPase; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 9.
DR PROSITE; PS50088; ANK_REPEAT; 10.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 455..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 1..27
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 28..60
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 61..93
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 94..126
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 127..159
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 160..192
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 193..225
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 226..258
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 292..324
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 325..348
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 398..909
FT /note="KAP NTPase"
FT /evidence="ECO:0000259|Pfam:PF07693"
FT REGION 1242..1279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1309..1397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1534..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1452..1466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1630 AA; 180284 MW; 5E1CDC2996A6B9B0 CRC64;
MLAAEQGSLE IVQELIRRGA NVNLDDVDCW SALISAAKEG HVEVVKELLE NSAYIEHRDM
GGWTALTWAA YKGRVEVAKL LLEHGANPNT TGQYSVYPII WAAGRGHADI VKLLLQNGAK
VNCSDKYGTT PLIWAARKGH FDCVMHLLEN GADVDQEGAN SMTALIVAVR GGYTEVVKEL
LKRNPNVNMT DKDGNTALMI AAKEGYTEIV QDLLDAGTYV NIPDRSGDTV LIGAVRGGHV
EIVRALLHKY ADIDIRGQEN KTALYWAVEK GNATMVRDIL QCNPDTETCT KDGETPLIKA
TKMRNIEIVE LLLDKGAKVS AVDKKGDTPL HIAIRGRSRR LAELLLRNPK DGRLLYRPNK
AGETPYNVDC SHQKSILTQI FGARHLSPSE TDGDMLGYDL YSSALADILS EPTMQPPICV
GLYAQWGSGK SFLLKKLEDE MKTFAGQQIE PLFQFSWLVV FLSLLLCGSI AIILGFSVDP
KLAMAVSLSL LALLYLFFVV VYFGGRREGD NWTWAWLLST RLARHIGYLE LLLKLMFVNP
PELPEQSTRA LPVRFLFTDY NRLSSVGGET SMAEMIATLS DACEREFGFL ATRLFRVFKT
EETQGKRKWK KTCCVPSFIL FTVVLACLVT GMALLAVFKV DGENRTVNAV LIAIGSVVGL
ALLLNCRTWW QVTDSVLNSQ RKRLHSAANR MHKLKSEGFM KVLKHEVELM ARMAKTIDGF
TQHQTRLAVV IDGLDSCEQD KVLQMLDTVR VLFSKGPFIS IFASDPHIII KAINQNLNSV
LRDSNINGHD YMRNIVHLPV FLNSRGLSSA RKMCTATPTN GDVTTADAGW HEELDRKLSQ
HSLGELTKFG SKTMLNRRET YRRRQVQRSV TRQMSFDLTK LMVTEDWFSD ISPQTMRRLL
NIVSVTGRLL RANQISFNWD RLASWINLTE QWPYRTSWLI LYLEETDGVP DHATLKTIYE
RVSKNIPTTK DVEPLLEIDG DVRSFEVFLS SRTPVLTARD IRTFLPCTVN LDPKLREIIA
DVRAAREQIN MGGVTYPPLP LQEAQPRPTS VYSQVSSTCS PSASFTGPFN PPAGGVVSPP
PHSSYYSGMA STQHPFYNRG SASVASATPP VLLSSMTTEA VCERVRHMEG IDQSMIGQYT
ATIRKANVNG RVLSQCNIDE LKKEMNMNFG DWQLFRATVL DMRHIESQVL HEETASEQGS
VIGGHIEPVR RVMAPPHAGA PNTDASPMYS FNLSFEELST VGLDDPQRHG NMPWMGGAHR
TASMTSLNSQ ESSNDISKLT DKQQAEYRDA YQEYIAQMAQ LELGVITGEK PIQPQPGQFM
TSSSEDKSKD GTEQDGRKSF NKRSSSKPAA DNTDFASNGE ALDPIREEDE KGDHGSSKSV
LTRKSSAERG GLFQGAADLK LKASGGLRYQ KLTSDDEESE ESDHAPLLKD GKKVVDPKLP
GGSLALKGKD YLSDAMLDKK DSSDSGVRSN ESSPNHSLQD EEADLSQLDR ANLIELDEES
LARKRGLPSS LSGLQDPAVA RMSICSEDQC SLLASSPEES WPSSRSYNLN RTPSNVTLNN
NTNAQQANRA RQPPEGSTSS NPSSSTSSTS EVIIPPMVHL KRGLKPGDPP EICTVSSDTV
TFGEERESIL
//
