ID A0A3B4FAM1_9CICH Unreviewed; 780 AA.
AC A0A3B4FAM1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Complement C2-like {ECO:0000313|Ensembl:ENSPNYP00000006968.1, ECO:0000313|RefSeq:XP_005754802.1};
GN Name=LOC102213554 {ECO:0000313|RefSeq:XP_005754802.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000006968.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000006968.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005754802.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_005754802.1; XM_005754745.2.
DR AlphaFoldDB; A0A3B4FAM1; -.
DR STRING; 303518.ENSPNYP00000006968; -.
DR Ensembl; ENSPNYT00000007142.1; ENSPNYP00000006968.1; ENSPNYG00000005354.1.
DR GeneID; 102213554; -.
DR GeneTree; ENSGT00940000165141; -.
DR OrthoDB; 3594820at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00033; CCP; 3.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR011360; Compl_C2_B.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46393:SF8; COMPLEMENT C2; 1.
DR PANTHER; PTHR46393; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00084; Sushi; 3.
DR Pfam; PF00089; Trypsin; 1.
DR Pfam; PF00092; VWA; 1.
DR PIRSF; PIRSF001154; Compl_C2_B; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00032; CCP; 3.
DR SMART; SM00020; Tryp_SPc; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..780
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041087027"
FT DOMAIN 106..165
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 168..225
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 276..474
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 495..770
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT ACT_SITE 536
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001154-1"
FT ACT_SITE 591
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001154-1"
FT ACT_SITE 712
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001154-1"
FT DISULFID 136..163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 196..223
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 780 AA; 87720 MW; 95C0575979453C4C CRC64;
MHPRSILWIL LLVLVHRGSL QKTDYDYVYE TYDDEEPVNC SVTESIKGGH VTYSKGGLVG
SVLTYHCGPE KYPSPVSYRT CEEHGEWSPM RLASGRLASR ATCKDVLCPA QLQLDHGDFW
PRDQWFAVGA TQSFSCQEGF TLYGSAERNC TLSGEWTGET PICNNHADDC DDPGIPPGAL
RSGGRFFRGE KLTYRCQTGL DLLGSAERFC LEHREWSGSK PRCHGPNTFD SPSAVAAAMT
GSLAGLMDVL SPDDKKKEES ISFGRTFRVA EVSRMHIYIL LDTSGSIERE EFEKSRDATI
ALIRKLDSYD VKLNFHVLSF ATEAKDIVDI IDEESGNIDD VIWSIMDFNY TSHGRKTGTN
IHGALKRVEE RMSIFKRNNN QFNETQNIII IATDGYSNTG KSAKIVLTKI RHLLGYSNPD
PDHTNEKMLD VYVFGVKEKV NKEELNFLAS KKRGETHVFI LKDYDKLGEV FNSIISDESV
TMCGVAQEDI SKDEQDGGKR AYTTPWHVTL KSPEWGKDKS CFGSIVSQNW VLTAAHCFAR
ESTGSVPRQL DIEYGLPPSQ SNVKFKRVIM HPSYSTSALK HRNVSEFYDY DVALVETNRS
IPLSWMARPI CLPCTVPGSR AMKKVNSTCA DHRVELLTLE QTPAFFNHKI SGSNERKETH
IHTGRQRLGC VENARKLVEH TDVTLDEFVP DRFLCSGGTA GYQDAITCQG DSGGSLFLQK
KKRYFQVGVV SWGIVDVCKI IGYTRRPPPD ARDFHIDLFK IMPWLKQHLG KEIQFLPEIN
//
