ID A0A3B4FBJ9_9CICH Unreviewed; 325 AA.
AC A0A3B4FBJ9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Homeobox protein orthopedia isoform X2 {ECO:0000313|RefSeq:XP_005720161.1};
DE SubName: Full=Orthopedia homeobox {ECO:0000313|Ensembl:ENSPNYP00000007940.1};
GN Name=otp {ECO:0000313|RefSeq:XP_005720161.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000007940.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000007940.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005720161.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_005720161.1; XM_005720104.1.
DR AlphaFoldDB; A0A3B4FBJ9; -.
DR STRING; 303518.ENSPNYP00000007940; -.
DR Ensembl; ENSPNYT00000008136.1; ENSPNYP00000007940.1; ENSPNYG00000006080.1.
DR GeneID; 102210944; -.
DR CTD; 560759; -.
DR GeneTree; ENSGT00940000159952; -.
DR OrthoDB; 5398847at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0071542; P:dopaminergic neuron differentiation; IEA:Ensembl.
DR GO; GO:0021884; P:forebrain neuron development; IEA:Ensembl.
DR GO; GO:0021767; P:mammillary body development; IEA:Ensembl.
DR GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR GO; GO:0007632; P:visual behavior; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR46770; HOMEOBOX PROTEIN ORTHOPEDIA; 1.
DR PANTHER; PTHR46770:SF1; HOMEOBOX PROTEIN ORTHOPEDIA; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 105..165
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 306..319
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 107..166
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 31..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 325 AA; 34847 MW; 5E112307A916A83A CRC64;
MLSHADLLDA RLGMKDAAEL LGHREALKCR LGGGGPDPGH SGELGPGPDG VEGTTMLPGD
DITSGGGSNP VQVNSKEQDK QQQQQQQNNN NSNNNPNQSG GQQPQKQKRH RTRFTPAQLN
ELERSFAKTH YPDIFMREEL ALRIGLTESR VQVWFQNRRA KWKKRKKTTN VFRAPGTLLP
THHGLPQFPS AAAAAAAMGD SLCSFHANDT RWATAGMPGV SQLQLPPALG RQQAMAQSLS
QCSLGAGPPP NSMGLSNMSS NGSGLQSHLY QPTFPGMVPA SLSGPTNVTG SPQLCSSPDS
DVWRGTSIAS LRRKALEHTV SMSFT
//
