ID A0A3B4FD17_9CICH Unreviewed; 2012 AA.
AC A0A3B4FD17;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRB {ECO:0000313|Ensembl:ENSPNYP00000007883.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000007883.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000007883.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR STRING; 303518.ENSPNYP00000007883; -.
DR Ensembl; ENSPNYT00000008076.1; ENSPNYP00000007883.1; ENSPNYG00000006016.1.
DR GeneTree; ENSGT00940000156088; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 10.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 14.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 17.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 13.
DR PROSITE; PS50853; FN3; 10.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..2012
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017254355"
FT DOMAIN 128..219
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 304..394
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 483..572
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 573..661
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 662..756
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 923..1013
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1014..1103
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1104..1194
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1281..1374
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1375..1469
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1736..1996
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1911..1987
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 372..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2012 AA; 221141 MW; A504D028B5A907CD CRC64;
MLRCAATCLI LGFVWGAKTV QTSEGPRCSA DLKEISSSSD SIAVQVTSAG LSCNFSLFCI
LDSWSSPAHC KSDGETSSAT ICNITGLQPG TVYQLTAVSR KDGEISHGTV QTDPVGPAHL
DLQLDPAQPH HKSLFMVLSS SALTVSWTQS TGRVDWYDVT LEDTSSGFRR RTRIKGSAAS
QTGFTSLIPG TLYKVSVVAS AGNKSASPVH AMTATAPSSV DGLQVASSSS HSLGVTWWIG
SGRTENLRVL LRDRAGVLLK NITLKNSSTS AELDGLHPGT PYTITVVTEA VGLQSSASTA
SVTAPAQVSR LVLENNGSSD HLRASWLPPK GGVESYLVTL RAPGSDTQLR HLLPNITQVE
FEGLTPGRSY EVSVSSSAGS QSTESRSTAR TVPDQVSALS MSADARTLWL RWLPPRGDWE
NYSVILKNGS VVLANETVSK ASRQHAFSVL SLVPGRLYSA EVTVHSGVLS NTARCSSQLA
PWPVQQLLVR QADETSLSVR WSRPPGQWDG FTVLLRWATA AATIVDQRVL GWEAKECTFN
SITPGGQYII TVTTNSGNLS SSASVTARTT PAQVSGLRLS NLGSTDSLQA RWAPASGYLD
SYQVLLVHDS SVIKNESVMA NISSLSFQAL RPGALYRVVV TTVRVGHISR QTVSEGRTVP
AAVSDVRVSN NGRMDFLSVS WSQAVGEVDR YLVTLSDRER TIHTLTVPKS TPTCVFDSLV
SGRLYNISIT TCSGLYKNQT FIQERTQPSK VQSPTATHNA SDSYLKVYWR HAAGDFDLYQ
VFIKHNNVFL QNKTVPKTEH NCVFTGLVPG RLYTVLVTTW SGKYEAIAST HGSTFPAAVR
SLTLAGRGTE DLRVTWMAAP GDVDHYEVQL LFSDMKVFPP ITLGSGVRDC VLSSLTPGRL
YKIIVSTYSG TNQKARYIEG RTVPSKVKNI HISNSGDSSS LMVSWTPGPG DVDGFSVFLY
RESRKLSTRS VLKHQNEVTF GSLQPGQVYT IMVQSVSGDL VNNNTVTGRT VPSAVTGLQV
DSHHTTCSIQ VSWQEALGVA DGYVLQVLDD RGSMVRNVSQ HFGHTWQQFD GLTPGKKYRV
VVQTTSGGVH SVGVSTEART NPAVVTNLAV TANTTTSLSF HWSPPEGDFQ LYEVFLYDRN
DQLHEKKRVQ SNSQQCTFQG LRPGAPYKML IQIHSGDQTN QTSIYTRTVP SAAAFLKAKS
GNQSDSLWVN WEHGGGDLSG YQLYLYNPNG SQQAMHQLGS EATGFIFSGL VAGRLYRAEV
LSQSGGLSNR ASTLGRTAPR PPASILFRGV TNTSLEITWS GPVDSDYDDF DLQWTPRDRL
SIINPYHTRT SSNRILRGMF PGRLYNFSLR TVSGTTEPGA TPTYSTPIRK SIRTKPERVH
SLHCRPQSST SISCSWVTPD TDYDSYTIEC LHKDSHTLMY SRLAEQDSNS YIITELEPHK
HYTVSVKVMS GGKPSDEAQD NVVTMLDRPP VPPSGTRVSE QSAVVTKSSI SFQFNCSWFS
DVNGAVKYFT VVVTESEDVS LMQLEQKHPL PSYLDYSSNS SIRSYQTSYF PSRCTESPDS
TTQSFNITLG TGMDLLGGTC DARGSDQDPE SSGELNHFCD GPLKPKTAYR ISVRAFTQLF
DDDAKDLSVL SPLFSDTCLS QPIITEAEPL SGVIEGVSAG LFLAAVIVGI TALFVCRHRT
RKVEEERLEV RINMRRERAA AGNQLGVRGR RISSPIKIVN FESHYSKLQA DSNYLMSEEY
EDLKDVGRNQ PLDSALLPEN RGKNRYNNIL PYDSTRVKLS YVDDDPCSDY INASYIPGNS
FRREYIATQG PLPGTKDDFW KMVWEQNVHN VVMVTQCVEK GRVKCDHYWP FDQDPLYYGD
LIVQMLSESV LPEWTIREFN IYSEEQLGFS RLVRQFHYTV WPDHGVPETT QSLIQFVRTV
RDYVNRTSGS GATVVHCSAG VGRTGTFIVL DRVLQQLDAK DTVDIYSAVF DLRLHRSHMV
QTEVQYAYLH QCVRDVLRAR KLRSEQEGMY RM
//
