ID A0A3B4FDS6_9CICH Unreviewed; 793 AA.
AC A0A3B4FDS6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Rho guanine nucleotide exchange factor 7-like {ECO:0000313|Ensembl:ENSPNYP00000007286.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000007286.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000007286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR AlphaFoldDB; A0A3B4FDS6; -.
DR STRING; 303518.ENSPNYP00000007286; -.
DR Ensembl; ENSPNYT00000007465.1; ENSPNYP00000007286.1; ENSPNYG00000005522.1.
DR GeneTree; ENSGT00940000155360; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11877; SH3_PIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..111
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 161..220
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 245..425
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 447..552
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 566..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 741..782
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 793 AA; 89295 MW; 4E4758A89A68FD57 CRC64;
MNSAEQTVTW LITLGVLESP KKSISDPEAF LQASLQDGAV LCRLLERLRP GTVDKFFQEP
RGDSECQRNI TEFVKGCGAF GVEPFEVNDL LQGLNFSKVL NSLVALNKAT EDLSVSGDTV
CVAHSSTSRI KSFDSLNTQS RSLKLLQPQY RSLDMSEGSG CGQLLVRARF PFQQTNEDEL
SFSKGDLIIV TRQEEGGWWE GTLKDKTGWF PSNYVRELKG NDKPKSGTLK SPPKGFDTTI
INKTYYNVVL QNILEAETEY SRELQSLLGS YLRPLHPTDR LSSVDIGHIQ ANLEDISTFQ
QMLVQSLEEH TKLPESQQRI GGFFLGLIPQ MKKIYLTYCS NHPSAVNVLT QHSEELKEYM
ESKGAPPPGI LALTTSLSKP FIRLDRYPTL LKELDRHMED QHPDRADLQA SMTAFKSLSA
QCKEVRKKKE LVLQILTEPI RNWEGDDIRT LGPVLHMSQA AVHSQNCPES NECYLLLFHH
TLLMVSASLR MSGFIYQGRI PLSGMLISRI EDGENLKNAF EISGSQGERI QVACNSQHDL
QEWLDLLTKH THAPAASTHK TLSVCHTLPS HPVTPSRNSE SRGGSSVSTY HTLPHVSLHG
MGISSPMWGP LEPPSTPKPW SLSCLRPAPP LRPSAALCYK EDMSKSPKNV KKLLPKRKPE
RKPSEEDFTV RKSTAALEED AQILKVIEAY CTSAKTRQTL NSSSSRKDVQ VLFPEEEKII
VEETRSNGQT VVEERSLVDT VYSLRDEVQE LKQDNKRMKR TLEEEQRARK ELERIVRRVL
KNMNDPTWDE TNL
//