ID A0A3B4FEC7_9CICH Unreviewed; 228 AA.
AC A0A3B4FEC7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
DE Short=FGF {ECO:0000256|RuleBase:RU049442};
GN Name=fgf5 {ECO:0000313|RefSeq:XP_013765653.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000008303.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000008303.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013765653.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays an important role in the regulation of cell
CC proliferation and cell differentiation. Required for normal regulation
CC of the hair growth cycle. Functions as an inhibitor of hair elongation
CC by promoting progression from anagen, the growth phase of the hair
CC follicle, into catagen the apoptosis-induced regression phase.
CC {ECO:0000256|ARBA:ARBA00025188}.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Affinity between fibroblast
CC growth factors (FGFs) and their receptors is increased by heparan
CC sulfate glycosaminoglycans that function as coreceptors.
CC {ECO:0000256|ARBA:ARBA00026062}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000256|ARBA:ARBA00007936, ECO:0000256|RuleBase:RU049442}.
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DR RefSeq; XP_013765653.1; XM_013910199.1.
DR AlphaFoldDB; A0A3B4FEC7; -.
DR STRING; 303518.ENSPNYP00000008303; -.
DR Ensembl; ENSPNYT00000008504.1; ENSPNYP00000008303.1; ENSPNYG00000006352.1.
DR GeneID; 102213645; -.
DR CTD; 2250; -.
DR GeneTree; ENSGT00940000158449; -.
DR OrthoDB; 2883843at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0061550; P:cranial ganglion development; IEA:Ensembl.
DR CDD; cd00058; FGF; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR PANTHER; PTHR11486:SF23; FIBROBLAST GROWTH FACTOR 5; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR PRINTS; PR00262; IL1HBGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Signal {ECO:0000256|RuleBase:RU049442}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU049442"
FT CHAIN 20..228
FT /note="Fibroblast growth factor"
FT /evidence="ECO:0000256|RuleBase:RU049442"
FT /id="PRO_5041472329"
FT REGION 174..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 228 AA; 26014 MW; F5D1E29372B9324B CRC64;
MNVPLYLLTF AHLICTAAGA QHVSLERQLL EEGIRSGRRT CRLYCRVGIG FHLQIHPDGR
VNGSHEPNQL SVLELFAVSQ GVIGIKGVYS NRFLAMNKRG RLHATEQFTD DCKFRERFQE
NSYNTYASVI HRNHRTGREW FVALNKRGKA KMGSSPRVKS QHVSTHFLPR VSMHDKGEQG
FTITDRSKER RKTPLPPPPK PPAAKANIQA GTTPRHTQVK YWPKYRFG
//
