ID A0A3B4FFE4_9CICH Unreviewed; 893 AA.
AC A0A3B4FFE4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Glutamate metabotropic receptor 2 {ECO:0000313|Ensembl:ENSPNYP00000008683.1};
DE SubName: Full=Metabotropic glutamate receptor 2 {ECO:0000313|RefSeq:XP_005741437.1};
GN Name=GRM2 {ECO:0000313|Ensembl:ENSPNYP00000008683.1};
GN Synonyms=grm2 {ECO:0000313|RefSeq:XP_005741437.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000008683.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000008683.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005741437.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR RefSeq; XP_005741437.1; XM_005741380.1.
DR AlphaFoldDB; A0A3B4FFE4; -.
DR STRING; 303518.ENSPNYP00000008683; -.
DR Ensembl; ENSPNYT00000008891.1; ENSPNYP00000008683.1; ENSPNYG00000006561.1.
DR GeneID; 102207802; -.
DR CTD; 336153; -.
DR GeneTree; ENSGT01030000234595; -.
DR OrthoDB; 5388627at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15447; 7tmC_mGluR2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001458; GPCR_3_mGluR2.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF147; METABOTROPIC GLUTAMATE RECEPTOR 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01052; MTABOTROPC2R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_005741437.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..893
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041073460"
FT TRANSMEM 588..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 589..855
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 893 AA; 99737 MW; 5684E3CB83320EED CRC64;
MSLGKAPVLG VRPQPRPLWL SNLSLLCLCV SLFAQAPQGL PVVGYNTDTK KEITLEGDLM
IGGLFPVHQK GEGAEDCGKI NAQRGIQRLE AMLLALDEIN KDEHFLHGLR LGAHILDTCS
KDTYALEQSL EFVRASLTKV DDSEYTCPDG SYAIHDDVPL AISGVIGGSY SDVSIQVANL
LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA MAEILRYFNW TYVSTVASEG
DYGETGIDAF QQEARARQIC IATSAKVSRS MSRWSYENVI RSLQQKSTAK VVILFTRSED
ARELLVAANR MNVTFTWVAS DGWGAQESVV RGSEAVADGA FTIELSSYQI PKFNDYFTSL
HPYNNTRNPW FREFWENQFQ CSLHDLGCGK HSLREVPFQP ESKIMFVVNA VYAMATALHN
MRQALCPNST KVCDALKPGN GRKFYRDYIL KVKIDAPFRP PDRDNIVRFD TFGDSLGRYN
IFHYHKDGER YVYRKVGYWA QSLSLNHSLI PWPGDVVPTS QCSDPCRKNE VKSMQPGDVC
CWICIPCQPY QYLHDEFTCA DCSFGQWPLA NLTGCYDLPE EYIRWEDAWA IGPVTIACLG
IMCTLFVIGL FLKHNETPVV KASGRELSYI LLLGVLMCYC MTFIYIAKPS TAVCTLRRLG
LGTSFAVCYS ALLTKTNRIA RIFSGVKDGA QRPRFISPAS QVAICGALIS CQLVVVVVWL
LVETPGVRKE VNPERRDVVT LKCNSKDSSM LMSLTYNCIL IILCTVYAFK TRKCPENFNE
AKFIGFTMYT TCIIWLAFQP IFYVTASDYR VQTTTMCISV SLSGSVVLGC LFAPKIHIIL
FQPQKNVSTL RVNTTRFSVN TGPGSSFSQA TASNVVPTVC NGREVVDSTT SSL
//
