ID A0A3B4FGZ7_9CICH Unreviewed; 2760 AA.
AC A0A3B4FGZ7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Fibrillin 3 {ECO:0000313|Ensembl:ENSPNYP00000009044.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000009044.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000009044.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 303518.ENSPNYP00000009044; -.
DR Ensembl; ENSPNYT00000009253.1; ENSPNYP00000009044.1; ENSPNYG00000006768.1.
DR GeneTree; ENSGT00950000183158; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 22.
DR Gene3D; 2.10.25.10; Laminin; 43.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF3; FIBRILLIN 2; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 34.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 2.
DR SMART; SM00181; EGF; 43.
DR SMART; SM00179; EGF_CA; 41.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 12.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 39.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 23.
DR PROSITE; PS50026; EGF_3; 37.
DR PROSITE; PS01187; EGF_CA; 13.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 107..139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 145..188
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 207..248
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 249..290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..348
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 441..480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 481..522
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 523..563
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 564..604
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 610..662
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 674..711
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 716..757
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 758..793
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 802..841
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 861..902
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 907..958
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 979..1020
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1021..1063
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1064..1105
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1106..1147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1189..1230
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1231..1268
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1273..1313
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1314..1352
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1355..1396
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1397..1433
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1438..1478
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1483..1532
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1581..1618
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1627..1670
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1691..1732
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1793..1828
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1832..1874
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1875..1914
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1915..1955
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1960..2013
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2029..2070
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2071..2110
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2152..2195
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2196..2237
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2242..2295
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2307..2344
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2349..2389
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2390..2426
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2429..2471
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2512..2548
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 111..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 129..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 445..455
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 762..772
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1797..1807
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2760 AA; 299572 MW; 3B8B637B0B3FA39B CRC64;
LVTFQDDVNT TLMAWMGPNV CGSRFHSYCC PGWKTLPGGN QCIVPICRNS CGDGFCSRPN
MCTCSNGQLS PSCGAGVQSC NVRCMNGGSC AEDSCLCTKG YTGNHCGQPV CENGCQNGGR
CIGPNRCACV YGFTGPQCER DYRTGPCFTQ VNNQMCQGQL SGIVCTKTLC CATIGRAWGH
PCEQCPAQPH PCRRGFIPNI RTGACQDVDE CQAVPGLCSG GNCINTVGSY ECKCPAGHRQ
SETTHKCEDI DECSTVPGVC DGGECTNTAG SYVCTCPRGY ISSTDGSRCV DQRAGTCFSA
LANGRCAADL TGQYTKMQCC CETGRCWALG QIPEMCPVRG SDEFRRLCIV GVPQVHGFSQ
HHNGHYPYGF KFPNGNDFVS VLSASRARFV SSGTVTVNET VDVCKHFTNL CLNGRCIPTP
TSYRCECNMG YKQDVRGECI DVDECVSNPC VNGDCVNTDG SYHCKCHEGY QGTPTKQACI
DIDECIVNGV MCRNGRCVNT EGSFQCICNA GFELTPDGKN CIDHDECATT NMCLNGMCIN
EDGSFKCICK PGFALAPSGR YCTDIDECQT PGICMNGRCI NSEGSFRCEC PPGLAVDVDG
RVCVDTHMRT TCYGAIKMGT CSRPFPGAVT KSECCCANPE HGFGEPCQPC PARNSAEFQA
VCSSGIGITA DGRDINECAL DPDICQNGIC ENLRGSYRCI CNAGYESDTS GKNCVDINEC
LVNRLLCDNG QCRNTPGSYT CFCPKGFVFK PESETCEDIN ECESSPCING ACRNVAGSFH
CECTHGSKLD STNTICVDSM KSTCWLTIQD NRCEVNINGA TLKSECCSTL GAAWGSPCEP
CEIDTACSRG FARMKGLVCE DINECEVFPG VCKNGRCVNT QGSFRCECAE GLTLDSSGRT
CVDMRSEQCY LKWHEDECGE PVPGRYRLDM CCCSVGAAWG VDCEECPTQG SPEYRAICPR
GHGFANRGDI LTGRPFYKDV NECKVFRGLC TYGACRNTIG SFRCRCNNGF ALTSDERNCT
DIDECRISPD LCGHGTCVNT PGSFECECFE GYESGFMMMK NCMDVDECER NPLLCQGGTC
LNTEGSYECE CPPGHALSTD GSACEDVNEC QLSDNLCKNG QCVNMMGTYQ CSCDTGYQAT
PDRQGCVDID ECTIMNGGCE THCTNSEGSY ECSCSEGYAL MPDLRTCADI DECEETPDIC
DGGQCSNIPG DYRCLCFDGF MASMDMRTCI DVNECDLNPN ICLHGDCENT KGSFICHCQM
GYFVKKGSTG CTDVDECEIG SHNCDMHAAC VNLPGSFKCR CRDGWVGDGI KCVDEDECAA
EDHNCNPNAD CVNTPGSYRC TCKEGFNGDG FSCSDMDECA DNVNLCENGQ CLNAPGGYRC
ECEMGFTPTE DSKACQDIDE CNFQNICVFG TCQNLPGMFR CVCDDGYELD RSGGNCTDIN
ECADPVNCIN GLCVNTPGSY LCNCPPDFEL NPTGVGCVDT RVGNCFLDVL ARGDGGISCS
AEIGVGVTRA SCCCSEGVAW GNPCELCPLL NSSMHRPTRF IYLQCLFPNA NLHVSLSRLQ
PTIRLCVREE KANSFPDIDE YIDECTTHTG ICGPGTCYNT LGNYTCVCPP EYMQVNGGNN
CMDMRKSVCY RNFNDTCENE LSFNMTKKMC CCAYNVGKAW NKPCEACPTP LLCGNQAPGF
IIDIHTGKPI DIDECREIPG ICAHGVCINQ IGSFRCECPM GFSYNNILLI CEECGNREEL
KRRKQQLLCK NISFRLSVAT FSVFHQCCTE FINRVVHRNI NALYVDVVLC VSDIDECERQ
PCGNGTCKNT VGSYNCLCFP GFELTHNNDC MDIDECSALQ GQVCRNGQCI NGLGSFQCLC
HEGYENTPDG KNCVDINECV SLPGTCSPGT CQNLDGSFRC ICPPGYEVQN DQCIDIDECV
DLSLCQFGTC TNTPGSFQCS CQPGFVLSDN KRRCYDTRES FCFTKFEAGK CSVPKAFNTT
KAKCCCSKMP GEGWGLPCEL CPRETDAAFN TLCPYGHGAL PGLGDAREDL NECLDNPGIC
QNGICINTDG SFRCECPFGY NLDYTGVNCI DTDECSIGNP CGNGTCTNVV GGFECSCEEG
FEPGPMMTCE DINECSQNPL LCAFRCMNTF GSYECMCPAG YVLRDDQRMC RDQDECSEGL
DDCDSKGMTC KNLIGTFMCI CPPGMQRRPD GEGCMDLNEC RTKPGICKNG RCVNIVGSYR
CECNDGFEPS STGTECIDNR KGFCFTEVLQ TMCQQSSTNR NSVTKSECCC NAGRGWGSQC
ELCPLPGTIQ YKKMCPLGPG YTTDGRDINE CQVMPDLCRN GQCINTIGSF RCHCNVGYKA
DFTATSCVDM DECALSPKPC NFLCKNTEGS YLCSCPRGYS LQPDGKTCKD LDECATKQHN
CQFLCVNTVG GFTCKCPAGF SQHQTACIDN NECTAQSSVC GSRASCINTP GSFNCECSKG
FSLDTTGFEC EDVDECSSNH RCQHGCQNML GGYRCGCPQG YVQHYQWNQC VDENECQGAS
VCGSASCYNT LGSYKCVCPS GFDFDQGAGG CQDVNECTTS TNPCIYGCSN TDGGYLCGCP
GGFYRAGQGH CITGSGFPGQ YVEGEDEDSL SPEACYECKI NGGGKNGRHK RDADENELSQ
VYLLLLLASI PVNISLASLL NKEPLLELLP ALQPLEHHVR YVITHGNADE HFHLLERRDG
KSVLRLGKKP PPPGSYRLEI ASLRLFGPRK LHQLEKQHDI DYLQGEIGDA LRIKLHVHLH
//