ID A0A3B4FH28_9CICH Unreviewed; 793 AA.
AC A0A3B4FH28;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Potassium voltage-gated channel subfamily B member 1 {ECO:0000256|ARBA:ARBA00015829};
DE AltName: Full=Voltage-gated potassium channel subunit Kv2.1 {ECO:0000256|ARBA:ARBA00031679};
GN Name=KCNB1 {ECO:0000313|Ensembl:ENSPNYP00000009218.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000009218.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000009218.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034100}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034109}.
CC -!- SIMILARITY: Belongs to the potassium channel family. B (Shab) (TC
CC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008292}.
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DR AlphaFoldDB; A0A3B4FH28; -.
DR STRING; 303518.ENSPNYP00000009218; -.
DR Ensembl; ENSPNYT00000009432.1; ENSPNYP00000009218.1; ENSPNYG00000007003.1.
DR GeneTree; ENSGT00940000154899; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003973; K_chnl_volt-dep_Kv2.
DR InterPro; IPR004350; K_chnl_volt-dep_Kv2.1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF63; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 1; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03521; Kv2channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01514; KV21CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR PRINTS; PR01495; SHABCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 184..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..138
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 469..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 793 AA; 89170 MW; 8910518223893EEB CRC64;
APMIKTGPRL GTTLPPDTID IIRSKTHSRR VRLNVGGLLH EVLWRTLDRL PRTRLGKLRD
CNTHDSILEI CDDYSLDTNE YFFDRHPGAF TSILNFYRTG KLHMMEEMCA LSFSQELDFW
GIDEIYLESC CQARYHQKKE QMNEELKREA ENMRERGGEE FTTTCCSEKR KKLWDLLEKP
SSSFAAKILA IISILFIVLS TIALSLNTLP ELQDTDEFDQ PTDNPQLAHV EAVCIAWFTM
EYLLRFLSSP SKWKFFKGPL NIIDLLAILP YYVTIFLTES NKSVLQFQNV RRVVQIFRIM
RILRILKLAR HSTGLQSLGF TLRRSYNELG LLILFLAMGI MIFSSLVFFA EKDEEDTKFK
SIPASFWWAT ITMTTVGYGD IYPKTLLGKI VGGLCCIAGV LVIALPIPII VNNFSEFYKE
QKRQEKAIKR REALERARRN GSIVSMNIKD AFGRSVELMD VMVEKSDEMK EKLQDNHVSP
NIHKGTAKNK SKTNPGSPTK TLESNYVEQA KPSSSPQHLS AQKLEELYNK MTKAQTQPSL
TGKEKGQPSK CRQRAQLEMG SIPNEAIPST LEVVRDMKST SSIDSFISCA TDLPESSRFS
QSPISNIPGK VSTNPSLETT LENEHEGATT PLTGKGTNSR GTHINNPLKS RSHKVNFRGG
EDSGTGVLSD SSSVQSPEAS IYTTASSRTP SKSPENLLPS MFTFHDASVS KFIDADTDEE
EHPHDGSVAS PAQRLLEKSS PKFGHRSTFQ QAPNHMEGLQ RKLGNSTLPL EGQENHVAQE
LQPLQGEKSH SNS
//
