ID A0A3B4FI24_9CICH Unreviewed; 395 AA.
AC A0A3B4FI24;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Transforming growth factor beta {ECO:0000256|PIRNR:PIRNR001787};
GN Name=TGFB3 {ECO:0000313|Ensembl:ENSPNYP00000010172.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000010172.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000010172.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Transforming growth factor beta-3 proprotein: Precursor of
CC the Latency-associated peptide (LAP) and Transforming growth factor
CC beta-3 (TGF-beta-3) chains, which constitute the regulatory and active
CC subunit of TGF-beta-3, respectively. {ECO:0000256|ARBA:ARBA00003972}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR001787}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR001787,
CC ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B4FI24; -.
DR STRING; 303518.ENSPNYP00000010172; -.
DR Ensembl; ENSPNYT00000010422.1; ENSPNYP00000010172.1; ENSPNYG00000007736.1.
DR GeneTree; ENSGT00940000155747; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-UniRule.
DR CDD; cd19386; TGF_beta_TGFB3; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR016319; TGF-beta.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR015618; TGFB3.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF34; TRANSFORMING GROWTH FACTOR BETA-3 PROPROTEIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF001787; TGF-beta; 1.
DR PRINTS; PR01423; TGFBETA.
DR PRINTS; PR01426; TGFBETA3.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001787-1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR001787};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246, ECO:0000256|PIRNR:PIRNR001787};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001787};
KW Signal {ECO:0000256|PIRNR:PIRNR001787}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT CHAIN 22..395
FT /note="Transforming growth factor beta"
FT /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT /id="PRO_5017107211"
FT DOMAIN 280..395
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT DISULFID 290..299
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 298..361
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 327..392
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 331..394
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 360
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
SQ SEQUENCE 395 AA; 45609 MW; 55491957E985AB03 CRC64;
MHLGKALLFV ILLNCATLSS SLSTCATVDI DHVKRKRVEA IRGQILSKLR LTSPPQSLGP
SKIPYQIQAL YNSTKELLEE LGRDRQQSCG QDNSETEYYA KEIYKFNMDN GPPENNDLSY
CPKGITSKVF RFNISAMERN ATNLFRAEFR ALRVPNSTAK RNEQRIELYQ IVRRNEHIRK
QRFIGAKNVL TKGTAEWISF DVTETVREWL MKRGSNMGLE ISVHCPFVHL DHVYNQGIDE
EEEHSRLDLD HLKRKMEQNL PHLILMMIPP HRLDTQSTRR RKRALDTNYC FSNTEESCCV
RRLHIDFRRD LDWKWIHEPS GYDANYCSGP CPYLRSSDTT HSSLLSLYNT LNPEASASPC
CVPQDLEPLT ILYYSGRTPK VEQLSNMIVK SCKCS
//
