ID A0A3B4FL56_9CICH Unreviewed; 173 AA.
AC A0A3B4FL56;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Transmembrane protein 208 {ECO:0000256|ARBA:ARBA00015033};
GN Name=tmem208 {ECO:0000313|RefSeq:XP_005746886.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000010484.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000010484.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005746886.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May function as a negative regulator of endoplasmic
CC reticulum-stress induced autophagy. {ECO:0000256|ARBA:ARBA00003220}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM208 family.
CC {ECO:0000256|ARBA:ARBA00009950}.
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DR RefSeq; XP_005746886.1; XM_005746829.1.
DR AlphaFoldDB; A0A3B4FL56; -.
DR STRING; 303518.ENSPNYP00000010484; -.
DR Ensembl; ENSPNYT00000010740.1; ENSPNYP00000010484.1; ENSPNYG00000007964.1.
DR GeneID; 102202727; -.
DR CTD; 29100; -.
DR GeneTree; ENSGT00390000008139; -.
DR OrthoDB; 2908595at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008506; SND2/TMEM208.
DR PANTHER; PTHR13505; TRANSMEMBRANE PROTEIN 208; 1.
DR PANTHER; PTHR13505:SF7; TRANSMEMBRANE PROTEIN 208; 1.
DR Pfam; PF05620; TMEM208_SND2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 154..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 173 AA; 19737 MW; C0EE95BBC811831D CRC64;
MAPKGKVGTK GKKQIYEENE ATLKFYTRVI LGANAIYAAV NFLVFYSSST FWTWLLLVFA
LAVYVGSYRS MAAMAKPAFA DDGSLLDGGI DLNMEQGMAE HLKDVILLTA IVQVLSTISS
YFWYLWLLAP ARALYLLWVN FLGPWFMAES PSAPEEVNEK KQRRQERRQM RRF
//
