ID   A0A3B4FNE9_9CICH        Unreviewed;       520 AA.
AC   A0A3B4FNE9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=KDEL motif-containing protein 2 {ECO:0000313|RefSeq:XP_005739123.1};
DE   SubName: Full=Protein O-glucosyltransferase 3 {ECO:0000313|Ensembl:ENSPNYP00000011253.1};
GN   Name=kdelc2 {ECO:0000313|RefSeq:XP_005739123.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000011253.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000011253.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005739123.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-
CC         (beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP;
CC         Xref=Rhea:RHEA:58116, Rhea:RHEA-COMP:14610, Rhea:RHEA-COMP:16010,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:58885, ChEBI:CHEBI:140576;
CC         Evidence={ECO:0000256|ARBA:ARBA00000570};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-
CC         (beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP;
CC         Xref=Rhea:RHEA:62016, Rhea:RHEA-COMP:16010, Rhea:RHEA-COMP:16011,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:57632,
CC         ChEBI:CHEBI:58223, ChEBI:CHEBI:132085;
CC         Evidence={ECO:0000256|ARBA:ARBA00000273};
CC   -!- SIMILARITY: Belongs to the KDELC family.
CC       {ECO:0000256|ARBA:ARBA00006063}.
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DR   RefSeq; XP_005739123.1; XM_005739066.1.
DR   AlphaFoldDB; A0A3B4FNE9; -.
DR   Ensembl; ENSPNYT00000011524.1; ENSPNYP00000011253.1; ENSPNYG00000008541.1.
DR   GeneID; 102211597; -.
DR   CTD; 143888; -.
DR   GeneTree; ENSGT00940000159028; -.
DR   OrthoDB; 1826823at2759; -.
DR   Proteomes; UP000261460; Unplaced.
DR   Proteomes; UP000695023; Unplaced.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR006598; CAP10.
DR   InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR12203; KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED; 1.
DR   PANTHER; PTHR12203:SF18; PROTEIN O-GLUCOSYLTRANSFERASE 3; 1.
DR   Pfam; PF00630; Filamin; 1.
DR   Pfam; PF05686; Glyco_transf_90; 1.
DR   SMART; SM00672; CAP10; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   PROSITE; PS50194; FILAMIN_REPEAT; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           38..520
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5041073526"
FT   REPEAT          37..146
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   DOMAIN          242..483
FT                   /note="Glycosyl transferase CAP10"
FT                   /evidence="ECO:0000259|SMART:SM00672"
SQ   SEQUENCE   520 AA;  59583 MW;  94E0BDEA27817037 CRC64;
     MACYRNVDVV EPFPSGLISR FVILLVFLST SFPVCDSEGI SPERCLIWGP GLNPDTVLPV
     RYFFIQAVNS KGENLTLSPG KDTFKVKIGS LDKNEYLRIH VPPPLDRGDG SFLLRYRLYS
     TAHKGLKIQV SYRDAAVASS PYTIQGPVHH EYCDCPEPDA SVWQSIMQCP ADDRQILADF
     KSFPTIDLQH LRQEVPHRFS NRGGLIHYAI INNHVYRRTL GKYTDFKMFS DEILLSLTRK
     VRVPDVEFYI NVGDWPLETK TSAAVPILSW CGSTDTRDIV LPTYEVTHST LETLRGVTND
     LLSVQGNTGP PWVNKTERAF FRGRDSREER LQLVSLSKNN PELLDAGITA WFFFRDQEKH
     VGKASLVGFF DFFKYKYQVN IDGTVAAYRF PYLMLGNSLV LKQDSQYYEH FYSHLKAGTH
     YIPVKRNLSD LLEKIRWAKE NDAEAQEIAR AGQAAARELL QPSRLYCYYY KVLHMYSERQ
     TGQPTRHADM ELVPQLDDHT APCKCERKSY KEETDGKDEL
//