ID A0A3B4FPY4_9CICH Unreviewed; 4444 AA.
AC A0A3B4FPY4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Dynein axonemal heavy chain 9 {ECO:0000313|Ensembl:ENSPNYP00000011336.1};
GN Name=DNAH17 {ECO:0000313|Ensembl:ENSPNYP00000011336.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000011336.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000011336.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 303518.ENSPNYP00000011336; -.
DR Ensembl; ENSPNYT00000011608.1; ENSPNYP00000011336.1; ENSPNYG00000008442.1.
DR GeneTree; ENSGT00940000154076; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1837..1973
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2115..2316
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2442..2588
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3017..3068
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3247..3295
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3602..3632
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4444 AA; 508216 MW; 126C531EDDAA3BC0 CRC64;
LLCHKKRNSL VAASGQESPA AEDERLDYIA ECVLRTLKLK QDKWQKCVSS EDNRQVLQEF
LDKAEQRTLV VSVTAGGQLQ TASSFTGDSK NKAVYFIKRT TTTLSPESMK ENLFYGDLSY
APLDQFSALV EEVIAPLLSN SNNYIQWPQV VVQDIKCHVH SLKNSVFVVS GQIQGKTLLP
LPAGSERIDR AALETDKSII HSLESAVIEW SHQIRDILKK DSSEALLEGR NPTPHTELLF
WKNRYADFKC IHSQLKSCKV NKMAALLEAV ESCYHAAFMN MQQDVLAALE EAEDICTYLR
PLQPLFTDME NVEIPAVKGL IGPLMHTVCL VWANSRYYNT PARLIVLLQE TCNLLIQQAR
IYLVPEDILR GEVSETLQKI QTTLEVLILF KSTYEDRRAN LRQYQKNGSL VRPWDFSPLL
IFSGLDRFVN RDILLTAVDL LKLEKLEIGG VRGRALSQQV QQLQQEFTDM YKFFTEKPYD
CLDEFEEDVR QFKLKVDDID RRLGAIFCQA FDDAFGLEHA FKVLDMFGSL LERPLVATDA
LDKYPLLVSM FDKELDCCKI LYNKHIQAAE EWGSAPVNKN MPAVAGGLRW AQEVEQRIQT
PFFKFRHLAY PCLETAEGAR VIQKYEEMMQ LLDRYSTSLY ETWTETVGES SQYNLSLPLI
KRDPDTQLIT VNFNPQLAAV LREVKYLVAR QTEAIPETAV QIYTIRGQLW QYVANLELTV
DRYNKVVHSV LDVERPLIQG QLSDIDAQLR KAEDSLNWNS QGVWEYIQEA RDLVCDLESR
LQRAKDNVEE ILSCMRSWST PIFDRKEGKK DALLSLEDRT ERLDRFYSLI RSSGEKIHFL
VKCNRALLKA EPSSEEWKAY VEYIDDTIID GFFNSIECSL RFFLDNTDQR AVIAPLFEAQ
LDLRVPDMVF TPSLEVGTRE SLFELVEGLI NDVFGISSLV PRLAQHSPFP NYQVQLDMAD
LADMRNLIME RIQAAMATCC EFRNSLERYS YLYVEDRKEF MRQFLLYGQI LTNQEMEIYP
DNSVSESPPS LGNFREQVNS YEKIYEEVQA LEPVHVFHRW MRVDGRSMKS ALLNIIKKWS
YMFKQHLVDL VTNSLLDLEK FITVVQAGLS QQVEEGDYDG LVEVMGNLLA VKERQNTTDT
MFEPLQQTIA LLKEYEQELP DVVYKQLEEL PDKWDNVKKQ AVLVKQQVAP LQAVEVSGLR
RKCAAFDVEQ HTFREHFRKS KLFRFESESP YQMLDAFHRQ IQEREAIMAS LVESASLFEV
TVSEYRQLRQ CRHEVVLLKE LWDMITMVES TMTAWRTTSW REINVDDMEL ECKRFSKEIR
ILDKEVRAWE AFTGLESRVR NLLTSLRAVA ELQNPAIRSR HWHQLMAATG VRFTMDQETT
LADLLQLNLH CFEDEVRGIV DKAVKEMGME KVLSELNSTW TGMQFQYEPH HRTKLPLLRA
NEELIETLED NQVQLQNLMS SKYIAHFLDE VSSWQSKLSV VDSVISIWFV VQRTWSHLES
IFLGSEDIRS QLPEDSRRFE GIDADFKELA NAMHETPNVV EATNKPGLFR KLEDIQSRLS
LCEKALAEYL DTKRLAFPRF YFISSADLLD ILSNGTNPHQ VQKHLSKLFD NMAKMRFETD
GEGNPSKIGQ GMYSKEEEYV PFNQACDCSG QVEMWLNRVL DTMRSTVRHE MTEAVIAYEE
KPREQWLFDY SAQVALTCTQ IWWTSDVTMA FARLEEGYDN AMKEYYKKQV SQLNTLISML
IGQLTPGDRQ KVMTICTIDV HARDVVAKMI TQKVRGNELK IFQHRWDEKE KHCLTNICDA
QFLYSYEYLG NTPRLVITPL TDRCYITLTQ SLHLTMSGAP AGPAGTGKTE TTKDLGRALG
IMVYVFNCSE QMDYKSCGNI YKGLAQTGAW GCFDEFNRIS VEVLSVVAVQ VKSIQDAIRD
KKQRFNFMGE EVNLCPSVGI FITMNPGYAG RTELPENLKA LFRPCAMVVP DFELICEIML
VAEGFLNARV LARKFITLYT LCKELLSKQD HYDWGLRAIK SVLVVAGSLK RGDPGRAEDQ
VLMRALRDFN IPKIVTDDMP VFMGLIGDLF PALDVPRKRD LDFEKGVRES ILDLKLQAED
NFVLKVVQLD ELLAVRHSVF VIGNAGTGKS QVMRSLHRTY QNMKRRPVWA DLNPKAVTND
ELFGIINPAT REWKDGLFSN IMRELANISH GGPKWIVLDG DIDPMWIESL NTVMDDNKVL
TLASNERIPL NPTMRLVFEI SHLRTATPAT VSRAGILYIN PADLGWNPPV SSWIDKRKAQ
SEKANLTILF DKYIPPCLEA LRSRFKKIIP IPEQSLVQML CYLLECLLTP ENTPADCAKE
LYELYFVFAA VWAFGGAMFQ DQLVDYRVEF SKWWVTEFKT IKFPTQGTVF DYYIDPKSKK
FEPWSKMVPK FEMDADTPLQ ACLVHTTETI RVRYFLDHLL EYRRPVMLVG NAGTGKSVLV
GEKLGSLDAE KYMIKNVPFN YYTTSAMLQA VLEKPLEKKA GRNYGPPGSR RLIYFIDDMN
MPEVDAYGTV QPHTLIRQHM DYNHWYERNK LLLKEIHNVQ YVSCMNPTAG SFTINPRLQR
HFSVFALSFP GAEALSTIYT SILSQHLRGE GFSAALQKSC STLVQLALAL HQRVSSAFLP
TAVKFHYIFN LRDLSNIFQG ILFCTGECLK APLDLLKIYL HESNRVYRDK LVEEQDFQLF
DRLQADTVKK FYEDMEETLE QTREMNLYCH FAHGQGEARY MAVESWSSLS KTLLEVLDSY
NEVNATLNLV LFEDAMAHIC RINRILESPR GNVLLVGVGG SGKQSLTRLA AFISNLEVFQ
ITLRKGYSIA DLKSDLASLY VKAGVKNIGT VFLMTDAQVA DEKFLVLVND LLASGNSSVR
PEVRGSGLMD TKENCWKFFI SRVRRQLKVA LCFSPVGSKL RVRSRKFPAV VNCTAINWFH
EWPQEALESV SFRFLEEVEN INPQVKESIS KFMAYVHMSV NQMSKEYLAN ERRYNYTTPK
SFLEQIKLYR SLLGQKSKDL TNKMERLENG LQKLNSTSAQ VDDLKAKLAA QEVELKQKNE
DADKLIQEVG IETEKVSKEK AVADEEEEKV AAIAVVVSGK QRDCEEDLAK AEPALLAAQD
ALNTLNKNNL TELKSFGSPV AAVTNITAAV MVLMAPGGKV PKDRSWKAAK VMMAKVDTFL
DSLINFNKEQ IPEACLKAIQ PYLQDPEFQP DLVASKSYAA AGLCSWVLNI VKFYEVYCEV
EPKRQALSKA NAELAAAQEK LAAIKSKINH LNENLAKLTA KFEKATADKL KCQQEAESTA
HTISLANRLV GGLASENVRW AEAVENFKKQ ERTLCGDVLL ITTFISYLGY FTKRYRVQLM
DSTWRPYLSQ LKVPIPVTHD LDPLTLLTDD ADVATWQNEG LPADRMSTEN ATILTSCQRW
PLMVDPQLQG IKWIKNKYGE DLQVIRIGQR GYLDAIERAL AAGDVVLIEN LEETLDPVLG
PLLGRETIKK GRYIKIGDKE CEYNPSFRLI LHTKLASPHY QPELQAQCTL INFTVTRDGL
EDQLLTAVVS MERPDLEQLK FDLTKQQNDF KITLKTLEDN LLSRLSSASG NFLSDTELVE
NLETTKRTAA EIEEKVKEAK VTETKINEAR EHFRPAAARA SLLYFTMNDL NKIHPMYQFS
LKAFSVVFQK AVLKAEPAEG LKQRVSNLID SITSSVFQYT TRGLFECDKL TYIAQLAFQI
LLMNKDINPV ELDFLLRYPV QPGVTSPVEF LSNHSWGGIK ALCSMEEFRN LDRDIEGSAK
RWKKFVESEC PEKEKFPQEW KSKSSLQRLC IMRALRPDRM TYAVRDFVEE KLGSKYVIGR
SLDFAVSFEE SGPATPMFFI LSPGVDPLKD VEKHGRKLGY TFDNKNLHNV SLGQGQEVIA
EQALNLAAKN GHWVILQNIH LVARWLGTLE KLLEQYGDGS NENFRVFISA EPSSTREGHI
IPQGILETSI KITNEPPTGM HANLHKALDN FNQDTLEMCA RENEFKSILF ALCYFHAVVA
ERRKFGPQGW NRSYPFNTGD LTISVNVLYN YLEANPKVPY DDLRYLFGEI MYGGHITDDW
DRRLCRTYLE EFVKPEMMEG ELYLAPGFPL PGNMDYNSYH QYIDDNLPPE SPYLYGLHPN
AEIGFLTQTS ETLFRTILEM QPRDRGVGEG SGTTREEKVH AVLEEILEKL PEEFNMAELL
GKAEDRTPYQ VVALQECERM NILTQEIRCS LHELSLGLKG ELTMTSDMEN LQNAIFLDMV
PESWTKRAYP SMSGLALWFT DLLARIRELE AWSADFSLPS AVWLAGFFNP QSFLTAIMQA
MARRNEWPLD SMCLQCDVTK KNREDFSSPP REGAYIHGLY MEGARWDTQT GLIVDARLKE
LTPTMPVMFI KAIPVDKWDN RNLYQCPVYK TRQRGPTYVW TFNLKTKENP SKWTLAGVAL
LLQI
//
