ID A0A3B4FQ77_9CICH Unreviewed; 387 AA.
AC A0A3B4FQ77;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Pseudouridylate synthase RPUSD4, mitochondrial {ECO:0000256|ARBA:ARBA00039953};
DE AltName: Full=RNA pseudouridylate synthase domain-containing protein 4 {ECO:0000256|ARBA:ARBA00041563};
GN Name=LOC102206698 {ECO:0000313|RefSeq:XP_005741526.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000012722.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000012722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005741526.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in mRNA = a pseudouridine in mRNA;
CC Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-COMP:14659,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00001166};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in tRNA = a pseudouridine in tRNA;
CC Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00036943};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine in 5S rRNA = pseudouridine in 5S rRNA;
CC Xref=Rhea:RHEA:47036, Rhea:RHEA-COMP:11730, Rhea:RHEA-COMP:11731,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00001896};
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DR RefSeq; XP_005741526.1; XM_005741469.2.
DR AlphaFoldDB; A0A3B4FQ77; -.
DR STRING; 303518.ENSPNYP00000012722; -.
DR Ensembl; ENSPNYT00000013032.1; ENSPNYP00000012722.1; ENSPNYG00000009652.1.
DR GeneID; 102206698; -.
DR CTD; 84881; -.
DR GeneTree; ENSGT00940000158436; -.
DR OrthoDB; 2901925at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF93; PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000695023}.
FT DOMAIN 124..299
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT REGION 32..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 43195 MW; 4EBDA30246A735D3 CRC64;
MNTCGRLPRV FNRSSGLDVL FCLVKPRTTC RQCPQTTPPL ARGQSTAANH TPGSDADDKP
RVRAVDLARK IRGEKSKTRE TAPPMSAQQR RVMELKRFSV QLQNVHPNVL AKHLHRSVLY
QDKDVVIVNK PYGIPVADDS DVTSITSVLP VLSKMMDGMK IKSDSQLIPC LGLEKDSTGT
LLLARRDEVV EHVLALNRNN KVERKYWVIT VGVPVPSEGL IDIPIIEREV TGPQPHYKMA
LSPLYRLNNE GDGVTKVRSH RQAHPALTKY RVLDSSSGCS LVELQPFTGV KHQMRVHMAF
ALGCPILGDH KYSHWSKLAP QKLPERVLGK LGIEQSKVRH LPLHLHARQL TLPGISQADV
NVSCPLPKYF TQTLGRLHIT LPDEKQT
//
