ID A0A3B4FSV9_9CICH Unreviewed; 825 AA.
AC A0A3B4FSV9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Prospero homeobox 1 {ECO:0000313|Ensembl:ENSPNYP00000012361.1};
DE SubName: Full=Prospero homeobox protein 1 {ECO:0000313|RefSeq:XP_005734466.1, ECO:0000313|RefSeq:XP_005734467.1};
GN Name=prox1 {ECO:0000313|RefSeq:XP_005734466.1,
GN ECO:0000313|RefSeq:XP_005734467.1, ECO:0000313|RefSeq:XP_005734468.1,
GN ECO:0000313|RefSeq:XP_013766671.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000012361.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000012361.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005734466.1, ECO:0000313|RefSeq:XP_005734467.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_005734466.1; XM_005734409.2.
DR RefSeq; XP_005734467.1; XM_005734410.2.
DR RefSeq; XP_005734468.1; XM_005734411.2.
DR RefSeq; XP_013766671.1; XM_013911217.1.
DR STRING; 303518.ENSPNYP00000012370; -.
DR Ensembl; ENSPNYT00000012664.1; ENSPNYP00000012361.1; ENSPNYG00000009378.1.
DR Ensembl; ENSPNYT00000012674.1; ENSPNYP00000012370.1; ENSPNYG00000009378.1.
DR GeneID; 102193857; -.
DR CTD; 5629; -.
DR GeneTree; ENSGT00940000154790; -.
DR OrthoDB; 2877587at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.10.500; Homeo-prospero domain; 1.
DR InterPro; IPR023082; Homeo_prospero_dom.
DR InterPro; IPR037131; Homeo_prospero_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR039350; Prospero_homeodomain.
DR PANTHER; PTHR12198; HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26; 1.
DR PANTHER; PTHR12198:SF10; PROSPERO HOMEOBOX 1A; 1.
DR Pfam; PF05044; HPD; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125,
KW ECO:0000313|RefSeq:XP_005734466.1};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155,
KW ECO:0000313|RefSeq:XP_005734466.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 665..823
FT /note="Prospero"
FT /evidence="ECO:0000259|PROSITE:PS51818"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 296..323
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 59..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 91244 MW; CEB78AADDE4C27E2 CRC64;
MPDHDSDSLL NRQTKRRRVD IGVKRTVGST SSSTAAVTTA TTDNIARAKA AIFSAMNSLS
SHSHHGSDTD SMECSIVQPH GGPGVVSASD SESKSNVLRK LLKRANSYED TMMPFPGTTI
ISQLLKNNIA KNGGGPERGE RGDRGDRGDS GFPGSGLSNA SSDAPQEDAC SNSSQDSTPQ
ECLSPFGRPP GLATFDIERL NDEHLRAKRA RVENIIRGMS HSPSVVVPAA TRHERDHDMD
GERDMELDCP PPQSQQQAPS SPRGGEVCSS SRENKRKQRL PQQQQQSFTQ LVCQRKEQKQ
EERRQLKLQL EDMQKQLRQL QEKFFQIYDS TDDSEHNDLH NDIGNMSEDS PARSDNGGDD
RGGDDLRSDN EMSDLDPGHF IDRARALLQE QALLADREKP RREGLSRNKG HGGPGSSMHA
EGKQLAETLK QELNSAMTQV VDTVVKVFAK PPRPTPQQAF PTLSIPPERF PTAVNGDNPN
FHTANQRLQC FGDVIIPNPL DSFTSMPGIP GATNDQTEAL PLVVRKTPSE HHHQASAVGA
HGGNHHPALH PSSLSASMGF SPPSFRHPFP LPLMGYPFQS PLGAPPGSYT GKDRNSPDSM
DLSRESTSLR TKMSSGHHLG HHHRSCSPAH PGSTAEGLSL SLIKSECSDL QDMADISPYS
GSNIQEGLSP NHLKKAKLMF FYTRYPSSNM LKMYFSDVKF NRCITSQLIK WFSNFREFYY
IQMEKFARQS INDGVTGAEE LSVSRDCELF RALNMHYNKA NDFEVPDRFL EVAEITLREF
FNAIVAGKDV DPSWKKAIYK VICKLDSEVP EIFKSPNCLQ ELLHE
//
