ID A0A3B4FSX8_9CICH Unreviewed; 700 AA.
AC A0A3B4FSX8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Cullin-3-like {ECO:0000313|Ensembl:ENSPNYP00000012381.1};
GN Name=CUL3 {ECO:0000313|Ensembl:ENSPNYP00000012381.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000012381.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000012381.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR AlphaFoldDB; A0A3B4FSX8; -.
DR Ensembl; ENSPNYT00000012685.1; ENSPNYP00000012381.1; ENSPNYG00000009350.1.
DR GeneTree; ENSGT00940000155066; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 315..567
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 609..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 80882 MW; E5BC196BA94E73DB CRC64;
MSNLKSGPKK DTKMRIRAFP VREDVLNSLN NNFLQTLNQA WNDHQTAMVM IRDILMYMDR
VYVQQNNVEN VYNLGLIIFR DQVVRYGCIR DHLRQTLLDM IARERKGEVV DRGAIRNACQ
MLMILGLDGR SVYEEDFEGP FLDMSAEFFQ MESQKFLAEN CASVYIKKVE ARINEEIERV
MHCLDKSTEE PIVKVVEREL ISKHMKTIVE MENSGLVHML KNGKTEDLAC MYKLFSRVPN
GLKTMCECMS SYLREQGKAL VSEEGEGKNP VDYIQGLLDL KTRFDRFLLE AFNNDRLFKQ
TIAGDFEYFL NLNSRSPEYL SLFIDDKLKK GVKGLTEQEV ESILDKAMVL FRFMQEKDVF
ERYYKQHLGR RLLSNKSVSD DSEKNMISKL KTECGCQFTS KLEGMFRDMS ISNTTMDEFR
QHIQTTSASL SGVDLTVRVL TTGYWPTQSA TPKCTIPPAP RHAFEVFRRF YLAKHSGRQL
TLQHHMGGAD LNATFYGAVK KEDGSELGMG GAQVTGSNTR KHILQVSTFQ MTILMLFNNR
EKCTFEEIQQ ETDIPERELV RALQSLACGK PTQRILTKEP KSKEIENGHV FTVNDQFTSR
LHRVKIQTVA AKQGESDPER KETRQKVDDD RKHEIEAAIV RIMKSRKKMQ HNVLVAEVTQ
QLRARFLPSP VVIKKRIEGL IEREYLARTP EDRKVYTYVA
//
