ID A0A3B4FZC6_9CICH Unreviewed; 820 AA.
AC A0A3B4FZC6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Epithelial cell transforming 2 {ECO:0000313|Ensembl:ENSPNYP00000015967.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000015967.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000015967.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4FZC6; -.
DR Ensembl; ENSPNYT00000016369.1; ENSPNYP00000015967.1; ENSPNYG00000011865.1.
DR GeneTree; ENSGT00940000156299; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR CDD; cd17733; BRCT_Ect2_rpt1; 1.
DR CDD; cd17732; BRCT_Ect2_rpt2; 1.
DR CDD; cd01229; PH_Ect2; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 3.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR026817; Ect2.
DR InterPro; IPR049396; ECT2_BRCT0.
DR InterPro; IPR049395; ECT2_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF21243; ECT2_BRCT0; 1.
DR Pfam; PF21242; ECT2_PH; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
FT DOMAIN 141..220
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 236..324
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 417..541
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 388..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 93227 MW; A9227CB673D2E456 CRC64;
MADSSILTLG TARSLLVDSS VYDSRIAETT KDHVFLGMGC EDGEDMLPKV ETRVVLVGEA
GRNRELAKAL QDINTPFIMT DSVQEFGDGE NTEFETVFVL TQFDSPEYNY LYKHEHRIVG
PPVVLHCAAK DEPLQFSCRP LYSTTMLNLS LCFTGFRNKE EMKNLVNLVH HMGGTIRKDF
STKVTHLVAY STHGEKYRLA VCMGTPILTP SWILKAWERR DDVNFHAGDE EFRTEFKVPP
FQDCVLSFLG FSEEEKANME ERTLKHGGMY LEVGNERCTH MVVEENLVKE LPFSPSKNLF
VVKQEWFWGS IQMDARAGES MYLYEKNDSP AMKKAVSLLS LTTPNSNRKR RRLKDTLAQL
TKETEISPFP PRKRPSAEHS LSIGSLLDIS NTPETCKGGE EKKPSKSSTP VLSKQSARWQ
VSKELYQTES NYVDILSTIL QLFKHPLEKE GQVGGPILAQ EEIKTIFGSI PDIYEVHTRI
KNDLEELLTD WSENRSVGNI ILKYSKELVK AYPPFVNFFE MSKETIVRCE KQKPRFHAFL
KLSCWTCLPP SLTCTHQFSL HLLATYRAFS FQANLLSSHR SLVYRVETIA LGDQPCDRGE
NVTLFLFNDC LEIARKRHKV INTFKSPLGQ TRPPPPLKHI ALMPLSQIRR VLDLQDTEEC
VNAFALVVRP PTEQENLLFS FQLAGEETVK SAWLRTLCRH VANTICRADA EDLIQCTDPD
SLQVSTKDMD STLSKASRAI KKTSKKVTRA FSFTKTPKRV IQRAFMANSP SDEKSQRLSC
ENRVGSSTTL AAHHSPSMVH LPTMFERKYH TFSRSTTHLF
//
