ID   A0A3B4G0C4_9CICH        Unreviewed;       440 AA.
AC   A0A3B4G0C4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=tRNA (guanine(10)-N2)-methyltransferase homolog {ECO:0000256|ARBA:ARBA00013960};
DE   AltName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 homolog {ECO:0000256|ARBA:ARBA00032604};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000015188.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000015188.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC       tRNA methyltransferase complex that mediates the methylation of the
CC       guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC       {ECO:0000256|ARBA:ARBA00002425}.
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DR   AlphaFoldDB; A0A3B4G0C4; -.
DR   Ensembl; ENSPNYT00000015574.1; ENSPNYP00000015188.1; ENSPNYG00000011467.1.
DR   GeneTree; ENSGT00390000018131; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR   PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR   PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
DR   PROSITE; PS51627; SAM_MT_TRM11; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT   DOMAIN          170..299
FT                   /note="UPF0020"
FT                   /evidence="ECO:0000259|Pfam:PF01170"
SQ   SEQUENCE   440 AA;  50218 MW;  E30C6F2539A7BE7A CRC64;
     MAAFSSRSCL QYLLHLAQDN LDFRLPSPFW CLDGLSEEDV HSIMARSVCA KSAFELWGHG
     QTHSELRTSL LNFPSEIMSP FMHKDSTYRI NVYTFNKTLL FADRIKRIDA LEYLPFEGRV
     SLKNPQHIFC LLEDYGTDPN NIPEDPNYIY FGRWIADGQR DLIRSHSVKN RHFIGNTSMD
     AGLSFIMANH ARVKQDDLVF DPFVGTGSLL VACSHFGAYV CGTDIDYNTI HGKGRSSRKN
     QKWRGPDENI RANLRQYGAQ KMYVDVMVSD ASKPAWRDAA LFDAIITDPP YGIREATRRT
     GSHKDIAKPA EESHVPVSQA YHLSDIFTDL LNFSAHHLVM GGRLVYWLPV YRPEYCEEMV
     PLHPCLQLIS NCEQTLSSHT SRRLITMEKI KEPEEFDSLA HLSDPRFSAY QGHNAFREKY
     FSGLNKKSTK ENNKSDVSGD
//