ID A0A3B4G334_9CICH Unreviewed; 4564 AA.
AC A0A3B4G334;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Plectin-like {ECO:0000313|Ensembl:ENSPNYP00000016489.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000016489.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000016489.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 303518.ENSPNYP00000016489; -.
DR Ensembl; ENSPNYT00000016899.1; ENSPNYP00000016489.1; ENSPNYG00000012480.1.
DR GeneTree; ENSGT00940000162855; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF20; PLECTIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 15.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 34.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 68..176
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 189..294
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 835..892
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1612..1746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2055..2075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2120..2175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2492..2512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4505..4564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 788..818
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1280..1331
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1623..1637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1650..1741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2055..2073
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4564 AA; 522463 MW; 069E97D27F7F043E CRC64;
MATRKDRRRD RTPLEESYEE RSGVPFLGDT LPWNLSKHQR VKRSKSATAE VLDPADRAVI
RIADERDRVQ KKTFTKWVNK HLIKHSRVES QRHVTDLYED LRDGHNLISL LEVLSGETLP
REKGRMRFHK LQNVQIALDF LRHRQVKLVN IRNDDIADGN PKLTLGLIWT IILHFQISDI
QVNGQSEDMT AKEKLLLWSQ RMTDGYQGIR CDNFTTSWRD GKLFNAVIHK HYPRLINMGK
VYQQTNLENL EQAFSVAEKD LGVTRLLDPE DVDVPHPDEK SIITYVSSLY DAMPRTDVHD
GMRTNELELR WQEYYELVTV LLQWIRHHVM IFEERKFPAS YEEIELLWRQ FLKFKETELP
VKETDKSRSK HIYQSFESAV HAGQVKVPPG YHPIDVEKEW GRLHVAILER ERLLRIEFER
LERLQRICGK VQKESGMCDE QLAHLETLLQ TDIRLLNAGK PAQHAAEVER ELDKADNVIR
LLFNDVQVLK DGRHPQAEQM YRRVYRLHER LVNLRTDYNL RLKSAVTTAQ VPITQSVQQT
SVKGRPELDD VTLRYVQDLL AWVEENQRRI DNAEWGSDLP SMESQLGSHR GLHQTVEDFK
SKIERAKADE TQLSPVSKAT YREYLGKLDL QYGKLLNSSK FRLRNLESLH AFVSAATKEL
MWLNDKEEEE VNFDWSDRNT NMTAKKDNYS GLMRELELRE KKVNDIQTLG DRLVRDGHPG
KKTVESFTAA LQTQWSWILQ LCCCIEAHLK ENTAYYQFFA DVKEAQDKMK KMQENMKKKY
SCDRSTTATR LEDLLQDAAE EKEQLNEFKT VVAGLNKRSR SIIQLKPRNP TTSIKGKLPI
QAVCDFKQQE ITVHKGDECA LLNNSQPFKW KVLNRSGHEA MVPSVCFIVP PVNKEAVDGV
SSLDAGHQGM VSMWQMLHIN MKSLLSWQYL MRDFTQIRSW NITMLKTMKP EEYRLIMRNL
ELHYQDFMHD SQDSQLFGPD DRMQVEDDYT KSTQHFDNLL RSMEKGIMVV RVKGQQNETL
CKNYISELKD LRLRIEDCEA GTVARIRKPV EKEPLKECIQ KTTEQKKVQG ELDSLKKDLD
KVSVKTQEVL ASPQPSTSAP VLRSELDLTV QKMDHAHILS SVYLEKLKTV EMVIRNTQGA
EGVLKQYEDC LREVHTVPSD VKEVETYRAK LKKMRTEAEG EQPVFDSLEE ELKKASAVSD
KMARVHSERD VELDHFRQQL SSLQDRWKAV FTQIDLRQRE LEQLGRQLGY YRESYDWLIR
WIADAKQRQE KIQAVPITDS KTLKEQLAQE KKLLEEIEQN KDKVDECQKY AKAYIDTIKD
YELQLVAYKA QVEPLVSPLK KTKLDSASDN IIQEYVTLRT RYSELMTLTS QYIKFITDTQ
RRLDDDEKAA EKLKAEERKK MAEMQAELDK QKQLAEAHAK AIAKAEKEAQ ELKLKMQEEV
SKREIAAVDA EKQKTNIQLE LQELKNLSEQ QIKDKSQQVD EALHSRTKIE EEIRLIRIQL
EITQKQKYTA ESELQQLRDR AAEAEKLRKL AQDEAEKLRK QVSEETQKKR QAEEELKRKS
EAEKEAAKQK QKALEDLENL RMQAEEAERQ VKQAEIEKEK QIKVAHEAAQ QSAAAELQSK
HMSFAEKTSK LEESLKQEHG AVLQLQQEAE RLKKQQEDAE NSREEAEKEL EKWRQKANEA
LRLRLQAEEE AHKKTLAQEE AEKQKEEAER EAKKRAKAEE SALKQKEMAE EELERQRKIA
DSTAQQKLTA EQELIRLRAD FDNAEQQRSL LEDELYRLKN EVAAAQQQRK QLEDELAKVR
SEMDILIQLK TKAEKESMSN TEKSKQLLEA EAAKMKDLAE EASRLRAISE EAKHQRQIAE
EEAARQRAEA ERILKEKLAA ISEATRLKTE AEIALKEKEA ENERLRRQAE DEAYQRKALE
DQANQHKQEI AEKIVQLKKS SEAEMERQKA IVDDTLKQRR IVEEEIRILK LNFEKASSGK
LDLELELNKL KNIADETHQS KIRAEEEAEK LRKLALEEEK RRREAEEKVK KIAAAEEEAA
RQRKAALEEL ERLRKKAEEA RKQKDEADKE AEKQIVVAQQ AAHKCSAAEQ QVQSVLAQQI
EDSITQKKLK EEYEKAKKLA KEAEAAKEKA EREAALLRQQ AEEAERQKAA AEEEAANQAK
AQEDAERLRK EAEFEAAKRA QAEAAALMQK QQADAEMAKH KKLAEQTLKQ KFQVEQELTK
VKLRLDETDK QKSVLDEELQ RLKDEVDDAV KQRGQVEEEL FKVKVQMEEL LKLKNKIEEE
NQRLIKKDKD STQKLLAEEA ENMRKLAEDA ARLSVEAQEA ARLRQIAEDD LNQQRALAEK
MLKEKMQAIQ EASRLKAEAE MLQKQKDLAQ EQAQKLLEDK QLMQQRLEEE SEEYHKSLEV
ERKRQLEIMA EAERLRLQVS QLSEAQARAE EEAKKFKKQA DTAAARLHET EIATQEKMTV
VERLEFERLN TSKESDDLRK AIADLENEKA RLKKEAEERQ NKSKEMADAQ QKKIEHEKTI
LQQTFMTEKE MLLKKEKLIE DEKKRLESQF EEEVKKAKAL KDEQERQKQQ MEQEKKTLQA
TMDAALSKQK EAEEEMLRKQ KEMQELERQR LEQERILAEE NQKLREKLQQ LEDAQKDQHT
RETVRHKDVI HLTTIETTKT VYNGQNVGDV VDGIDKKPDL LAFDGIRDKV PASRLHELGV
LPKKEFDKLK NGETTVEELG KTDSLRNILK GKNAIGGVLT PSNQKMSIYQ ASKEKKITPG
TAMILLEAQA ATGYMLEPIK NQKLSVNAAV KEGLIGPELH NKMLLAERAV VGYKDPYTGG
KISVFEAMKK GLIEHDHAIR VLEAQLATGG IIDPINSHRV PTETAYKQGH YDAEMNKIME
NPSDDTKGYF DPSTQEPLTY SELMARCTTD PETSLLLLPI TDKAAQCSSI YTEEETKDVF
GKTTVSVPFG RFKGKTVTIW EIINSEYFTE DQKKDLLRQY KTGKITIEKI IKIVITVAEE
KEKKNEITFD GLRAPVPATD LLESKIIDKD LYNKLHNGNM TVSEVSQMEP VHKALKGTNC
IAGVVIDSSK ETMSFYQAMK KDMMRPGPAL NLLEAQAGTG YLVDPVHNQK YTVDEAVKAG
VVGPELHEKL LSAERAVTGY RDPYTGKAVS LFQAMKKDLI PKEQGLRLLD AQMTTGGIID
PVKSHRIPHD VACKRNYFDD EMKQALSNPN DETKCFFDPN TKENLTYSQL FDRCVTDKKT
GLRVLPLSDE AINAKEQPAY TEAQTKEAMT QATVEVNSGP FKGRKMTLWE IIYSEYLTEE
ERLDLLRQFR SGKITIEKII KIIITIVDEK EAKKQEQSSF KGLRAPVPAD SLYESKIIDK
PTFDLLQQGK TTPKKVSENP NVSKYLQGSS SIAGLYLEPT KEKLSIYQAM KKKLLRHNTG
LSLLEAQAAS GFIVDPVRNQ CLSVDEAVKS GVVGPELHEK LLSAEKAVTG YKDPFTGHKI
SLFEAMQKDL ILKEHAMPLL EAQIVSGGII DPVKSHRVPT DVAYQKNILS RDIAKTLSEP
CDENKVFSDP ETDDTITYRQ LKDKCQKDKD TGLYMLSLSK PQSPTVVEKT YLYTEEQTQS
ELSSTQLDIP IEGLADKPMN LWDIMNSNLL PEQERQKLLD EYRSGKITKE RMIIIIIEIM
EQREIIRNDS PLSYMTIRRR ITIEELYNAR IIDLETYNLL KQGKRDIRNI MELTSVKQYL
YGTGCVAGVT TDSTSKLSIY QAMKRGFIKP EIGLTLLEAQ AATGFIVDPL KNETLTVDEA
VRKGVVGPEI HDKLLSAERA VTGYKDPYSG KIIALFQAMK KDLVPEDYAL KMLEAQTATG
GIIDPEFQFH LPTDVAMQRG YINKETNEKL NDDVKGFIDP VTDEKLSYAQ LLKRCKLDGG
LRLLSLGDQR LTFKGLRKQI TIEELIRSQI IDQQTVTDLN EGLVSVEEIS NRLSRYLQGT
GCIAGVFLES TKERLSIYQA MKKNMIRPGT AFELLESQAA TGYVIDPIKN LKLTVNEAVK
MGIVGPEFKD KLLSAERAVT GYRDPYTGKT ISLFQAMKKG LILKDHGIRL LEAQIATGGI
IDPEESHRLP VEVAYNRGFF DEEMNEILTD PSDDTKGFFD PNTEENLTYL QLMERCITDP
DTGLVLLLLK EKKRERKTSS KSSVRKRRVV IVDPETGKEM TVYEAYRKGL IDHQTYLELA
EQECEWEEIT MTSSDGTVKS VIIDRKSGRQ YDVDDAIARG FIDQKALETY RAGNLSITEF
ADLLSGNMGG FRSRSSSFGS TTGSTYSSSM SPLPSIKPPA VIWNDPTEET GPVAGILDID
TLEKVSVTEA IHRNLVDNIT GQRLLEAQAC TGGIIDPTSG ERYSIAEATE KGLVDKIMVD
RLNLAQKAFN GFEDPRTKVK MSASQALKKG WLYYEAGQRF LEVQYLTGGL IEPDVEGRVS
IDESIRKGTI DARTAQKLRD VGAYSKYLTC PKTKLKISFK DAMDKSMVEE GSGLRLLEAS
SQSSKGLYSP YNASGSGSAY GSRSGSRTGS RSGSRRGSID AGSGFSMNFS SSSFTSSSGY
SRRF
//
