ID A0A3B4G402_9CICH Unreviewed; 405 AA.
AC A0A3B4G402;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Recombining binding protein suppressor of hairless-like protein {ECO:0000313|Ensembl:ENSPNYP00000017600.1};
GN Name=RBPJL {ECO:0000313|Ensembl:ENSPNYP00000017600.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000017600.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000017600.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Su(H) family.
CC {ECO:0000256|ARBA:ARBA00009704}.
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DR AlphaFoldDB; A0A3B4G402; -.
DR Ensembl; ENSPNYT00000018036.1; ENSPNYP00000017600.1; ENSPNYG00000013213.1.
DR GeneTree; ENSGT00390000005197; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.1450; LAG1, DNA binding domain; 2.
DR InterPro; IPR015350; Beta-trefoil_DNA-bd_dom.
DR InterPro; IPR036358; BTD_sf.
DR InterPro; IPR040159; CLS_fam.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR015351; RBP-J/Cbf11/Cbf12_DNA-bd.
DR InterPro; IPR037095; RBP-J/Cbf11_DNA-bd_sf.
DR InterPro; IPR038007; RBP-Jkappa_IPT.
DR PANTHER; PTHR10665; RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS; 1.
DR PANTHER; PTHR10665:SF2; RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN; 1.
DR Pfam; PF09270; BTD; 1.
DR Pfam; PF09271; LAG1-DNAbind; 2.
DR Pfam; PF20144; TIG_SUH; 1.
DR SMART; SM01268; BTD; 1.
DR SMART; SM01267; LAG1_DNAbind; 1.
DR SUPFAM; SSF110217; DNA-binding protein LAG-1 (CSL); 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 21..128
FT /note="RBP-J/Cbf11/Cbf12 DNA binding"
FT /evidence="ECO:0000259|SMART:SM01267"
FT DOMAIN 64..201
FT /note="Beta-trefoil DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01268"
SQ SEQUENCE 405 AA; 45624 MW; 144CEDD17F755C77 CRC64;
QVIVVNGKTW WLPQETAADQ SVTILHAKVA QKSYGNEKRF FCPPPCVYIT GHGWKCNKSH
THAVCVSRQQ MFACAKTLFI SDQDKRKHFC LLLRLFLNNR QEVGSFQSRM IKVISKPSQK
RQSMKNADPK VLHLQVIRKV NKQHAILDVD EPVSQLHKCA FQFRDNPHAY LCLTNDAIIQ
YQAPFSVRDP SKVVLNDGSC WTIIGVEVVE FTFNQGLACI TTPVSPFPVV TGLEVNGGGH
VAMLEIHGEN FTPHLKVWFG NGEAETMYKS PKSLLCVVPD VSVFSDGWRC LRRVITVPLS
LVRLDGLIYR TSYSFTYTPE LQPPPSARMT AGGGKREGGM GNRTSLSSCT LFPFLSSSSS
ALTTQICVRE RRKETGRSTR PYGHWLLISV MWEKLQTERF SCPKQ
//
