ID   A0A3B4G414_9CICH        Unreviewed;       367 AA.
AC   A0A3B4G414;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Dickkopf-related protein 3-like {ECO:0000313|Ensembl:ENSPNYP00000016829.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000016829.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000016829.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the dickkopf family.
CC       {ECO:0000256|ARBA:ARBA00010842}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B4G414; -.
DR   STRING; 303518.ENSPNYP00000016829; -.
DR   Ensembl; ENSPNYT00000017250.1; ENSPNYP00000016829.1; ENSPNYG00000012765.1.
DR   GeneTree; ENSGT00390000000221; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR   CDD; cd23274; Dkk3_Cys2; 1.
DR   Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR039863; DKK1-4.
DR   InterPro; IPR047300; Dkk3_Cys2.
DR   PANTHER; PTHR12113:SF8; DICKKOPF-RELATED PROTEIN 3; 1.
DR   PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR   Pfam; PF04706; Dickkopf_N; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          209..258
FT                   /note="Dickkopf N-terminal cysteine-rich"
FT                   /evidence="ECO:0000259|Pfam:PF04706"
FT   REGION          168..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   367 AA;  40020 MW;  EDDED0DAEAB68B5E CRC64;
     MTPTSQMGTL TIAQMIKQQT TRNDGPHLSP RAPVSFSVAD AWTHVPVFYA VEQGRKHIAE
     RKEKVYNTSL AMMTTSFHSG ITATPSSECS SSILSSSMVP AILLVLSVTA VCNGILPEIV
     DPGISHILED DSAQGQAEPD SVFVEVEQLP EDPQQKPEDS FHQINEENSQ SSLHNANASD
     KVTDKDQETN NITTVDSSND LENRVDHGCI SDDDCGKGRY CLHDPHNAKC LPCKALDMSC
     TKDAECCGEQ LCVWGQCSQN ATKGEAGSTC QYQTDCSPDL CCAFHNVLLF PVCSAKPIER
     ERCFGASNHL TELLSWGPQD EGPRKYCPCA GDLHCQDLGR GSMCLKGEDS SEEDLTDTLY
     SEIDYIL
//