ID A0A3B4G4D8_9CICH Unreviewed; 2291 AA.
AC A0A3B4G4D8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=CHD7 {ECO:0000313|Ensembl:ENSPNYP00000016608.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000016608.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000016608.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR STRING; 303518.ENSPNYP00000016608; -.
DR Ensembl; ENSPNYT00000017021.1; ENSPNYP00000016608.1; ENSPNYG00000012490.1.
DR GeneTree; ENSGT00940000153649; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031223; P:auditory behavior; IEA:Ensembl.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0022010; P:central nervous system myelination; IEA:Ensembl.
DR GO; GO:0021602; P:cranial nerve morphogenesis; IEA:Ensembl.
DR GO; GO:0048546; P:digestive tract morphogenesis; IEA:Ensembl.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0120054; P:intestinal motility; IEA:Ensembl.
DR GO; GO:0022011; P:myelination in peripheral nervous system; IEA:Ensembl.
DR GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
DR GO; GO:0014029; P:neural crest formation; IEA:Ensembl.
DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:Ensembl.
DR GO; GO:0048840; P:otolith development; IEA:Ensembl.
DR GO; GO:0048935; P:peripheral nervous system neuron development; IEA:Ensembl.
DR GO; GO:0035845; P:photoreceptor cell outer segment organization; IEA:Ensembl.
DR GO; GO:0043473; P:pigmentation; IEA:Ensembl.
DR GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0060319; P:primitive erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0046549; P:retinal cone cell development; IEA:Ensembl.
DR GO; GO:0009303; P:rRNA transcription; IEA:Ensembl.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR GO; GO:0048798; P:swim bladder inflation; IEA:Ensembl.
DR GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0007632; P:visual behavior; IEA:Ensembl.
DR CDD; cd18663; CD2_tandem_CHD5-9_like; 1.
DR CDD; cd17995; DEXHc_CHD6_7_8_9; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.40.5.120; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR46850; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR PANTHER; PTHR46850:SF3; DNA HELICASE; 1.
DR Pfam; PF07533; BRK; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00592; BRK; 2.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF160481; BRK domain-like; 2.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 182..224
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 280..454
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 602..772
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1428..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2205..2291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..909
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1520..1536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2212..2227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2228..2247
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2265..2279
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2291 AA; 257221 MW; C24C7FEA7402048B CRC64;
LYFVSEGGAS AAKKDSKRKR EFSVNDDAEV KSPPLSPPEE EDDDGVQKRR SSRQVKRKRY
TEDLEFRISE DDDSGDDSPS PKSPSSSSQQ QDVAEAEGPV VEKIMGMRTS KKQVSCTDPH
PNDTNTIHRS TGCSYLHCRW ADLEELEKDK RIHQKVKRFK AKQQLNTFIT EMDDEPFNPD
YVEVDRVLDV SESTDENGET VTLYLVKWCS LPYEDSTWEL KADIDQSKID EFERIGARTP
NTKRVDRPPA ADWKKLEGSR EYRNGNALRE YQLEGLNWLT FNWYNSRNCI LADEMGLGKT
IQSITFLYEI YMKGIEGPFL VIAPLSTIPN WEREFRTWTE LNVVVYHGSQ ASRKTIQAYE
MYYRDAQGKI IKGVYRFHAV ITTFEMILAD CPELRSIPWR CVVIDEAHRL KNRNCKLLEG
LKMMDMEHKV LLTGTPLQNT VEELFSLLNF LEPERFPSEQ TFMTEFGDLK TEEQVQKLQG
ILKPMMLRRL KEDVEKNLAP KEETIIEVEL TNIQKKYYRA ILEKNFSFLS KGGAGGAGGG
GASVPNLLNT MMELRKCCNH PYLINGAEEK IIEEFRDSHS CGADMPDMAL QAMIQAAGKL
VLIDKLLPKL KAGGHRVLVF SQMVRCLDIL EDYLIQKRYP YERIDGRVRG NLRQAAIDRF
SRPDSDRFVF LLCTRAGGLG INLTAADTCI IFDSDWNPQN DLQAQARCHR IGQSKSVKIY
RLITRNSYER EMFDKASLKL GLDKAVLQSM SGRENANSGV QQLSKKEIED LLRKGAYGAL
MDEEDEGSKF CEEDIDQILQ RRTHTITIES EGKGSTFAKA SFVATGNRTD ISLEDPDFWQ
KWAKKAELDL DAINGRNTLV IDTPRVRKQT RHFSSVKEEE MLEFSELESD EDEPSKPSSK
PRRPQDKTQG YPRSECFRVE KNLLVYGWGR WSDILAHGRF KRPLKESDVE TICRALLAYC
LLHYRGDENI KSFIWDLITP SEDGTTRTLT NHSGLSTPVP RGRKGKKGKP QAPPPQTPRA
DWLASCNPDH LLQEDSYKRH LKHHCNKVLL RVRMLYYLRQ EVIGDQAERI LEGADSSLSS
APIPLPSPCH PDVNAFIMWN TCYEKYNSMR ADPALCFLER VGMPDAKAIA AEQRGSDMMA
DGVEGEDEDP EYKPLRMPFK DDMDDFTNSP LDDKDEGVEG ENEAKSDENS QRAPASNERL
YWPAASALTA RLRRLITAYQ RSNRREQLPA PYIQDGAGMF MAEGSPYLAK GSAYFVKGGQ
WTRREEADFY RVVSTFGVVF DTKRQKFDWT QFRAFARLDK KTDESLEKYY YSFIAMCKRV
CRMQVKTETE LPDPTLIIDP ITEERASRTL YRIELLRRIR EQVLPHPQLS ERLKLCQPSP
DLPEWWECGR HDRDLLLGAS KHGVSRTDYH ILNDPTLAFL EAHQRFTSQR GEGDANNIPC
AKIETPDEQK EHEGEIREDK DETAASQSKE IKKEEEVQPK AENEEEEVHK EEQSGEEEKL
TNDQDKDLTE EKNGTLGDQK DTLAELQHSS PKVQPAQKTA EEEDGEEKEN PESPKSPKSA
DTEKSPEEEE EERLDEDDKS EKSSQAEVSA ASEQKNFDEE SIASLSTSAR DETRDGFCPD
DLPETSALQA LQDRAFGFSF WPKDRVMINR MDNICEAVLK GKWPVNRRHV FDFPGNLLPG
HGSSATTAAA AMATESPLQR RSLAELTMAG IHTPFSGSED KTLSPQVHVS ETLSLTVPRQ
RRRRRKKIEI EAERAAKRRN LMEMVAQLRE SHAAAESQSQ AIDLTKASPS LTSFSSALVT
NSSLKAQMDL LQQGPATGHR ANGSLEADLP VIRRRRGRRK NVEGLELLAN VSPSARSLAS
GNLEEEETAV SNKELGEWLR QHPTYTMDMP GFTPKNEDLL LSPFSKPKQK RHRCRNPNKI
DINTLTGDER VPVVNRRNGR KMGGAMAPPM KELPRWLLEN PEFSIAPDWT DIVKQSGFLP
EAMFDRLLTG PVVREEGVRR RGRRPKSEIA KAAAASLATA ASSAGGINPL LLNSLFGGMD
LSSLQSLQSL QLAAGLMAFP PPTDPKQAAA NAAAASMLPL MLPGMGGLPN MATALPNMFS
LGGLFGENRN EASLSEDAVA SQIPAADSSA EATINGDAAT LLAAAGMSAN TLAFNPFLLS
TMAPGLLYPS MFLPPGLGGL SLPGFPTASN LAELQNAMAG ALGGSAGTPN VLRDQEKEDK
KADLKAAAEE EEEEEEEDEE GGGESDLAEE KEGEMRSEAD YSALEDGGMG EEEEEAAAEE
AAASSQKDKS D
//
