ID A0A3B4G593_9CICH Unreviewed; 402 AA.
AC A0A3B4G593;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=E3 ubiquitin-protein ligase TRIM13 {ECO:0000313|RefSeq:XP_005733920.1, ECO:0000313|RefSeq:XP_005733921.1};
DE SubName: Full=Tripartite motif containing 13 {ECO:0000313|Ensembl:ENSPNYP00000018047.1};
GN Name=trim13 {ECO:0000313|RefSeq:XP_005733920.1,
GN ECO:0000313|RefSeq:XP_005733921.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000018047.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000018047.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005733920.1, ECO:0000313|RefSeq:XP_005733921.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC {ECO:0000256|ARBA:ARBA00008518}.
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DR RefSeq; XP_005733920.1; XM_005733863.2.
DR RefSeq; XP_005733921.1; XM_005733864.1.
DR AlphaFoldDB; A0A3B4G593; -.
DR STRING; 303518.ENSPNYP00000018047; -.
DR Ensembl; ENSPNYT00000018495.1; ENSPNYP00000018047.1; ENSPNYG00000013639.1.
DR GeneID; 102196829; -.
DR CTD; 10206; -.
DR GeneTree; ENSGT00940000159715; -.
DR OrthoDB; 5383069at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF609; E3 UBIQUITIN-PROTEIN LIGASE TRIM13; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT TRANSMEM 314..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..56
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 87..129
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
SQ SEQUENCE 402 AA; 45466 MW; C16ED5A07AD1A3A4 CRC64;
MEQLEEELTC PICCGLFEDP RVLLCSHSFC KKCLEGLLEG NRGPAFRTPF KCPTCRKETP
HNGANSLQIN YSLRGIVEKF SKIKVIPKMS ACKQHSGQPL NIFCATDLKL ICGFCAATND
HEGHKFCSLE DAYEREKKAF DELLCGVKNW RSADYLSCLD TLQASKKRAL LSVSKDAEKV
KNYFEKLISA LECKKNEILS DFETLKLVVM QAYDPEISKL SAALEEQKRA LSIAGSFGSV
SDTLCFLQQM QEFRDKLKLL NNTPLPSRKD MDVGPLVRNF DVKNWDSLRL REVDRMSVPH
ESGSYRIGNK RMAVPRWISI LILTLISSLV LPLLLPHTFT AYVTWEAESI LAALFSLFAH
TGACLQEIKN IYIYVVDAGQ KYIMQLIDST ARFIDSYKLP TN
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