ID A0A3B4G660_9CICH Unreviewed; 1021 AA.
AC A0A3B4G660;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=FERM domain containing 4A {ECO:0000313|Ensembl:ENSPNYP00000018360.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000018360.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000018360.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4G660; -.
DR STRING; 303518.ENSPNYP00000018360; -.
DR Ensembl; ENSPNYT00000018820.1; ENSPNYP00000018360.1; ENSPNYG00000013853.1.
DR GeneTree; ENSGT01020000230354; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13191; FERM_C_FRMD4A_FRMD4B; 1.
DR CDD; cd17199; FERM_F1_FRMD4A; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR041785; FRMD4A/B_FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46079:SF3; FERM DOMAIN-CONTAINING PROTEIN 4A; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
FT DOMAIN 5..302
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 345..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..567
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 112729 MW; D2E0E38F55B33002 CRC64;
MTEGRRCQVH LLDDRKLELL VQPKLMAKDL LDLVASHFNL KEKEYFGIAY TDETGHFSWL
QLDRRVLEHE FPKKSGPIVL YFCVRFYIES ISYLKDNATI ELFFLNAKSI IYKELIEVDS
EVVFELASYI LQVSFNDATR SDLKKLPALP TQALKEHPSL AYCEDRVIEH YKKLSGQSRG
QAIVNYMSIV ESLPTYGVHY YSVKDKQGIP WWLGLSYKGI FQYDYQDKVK PRKVFQWRQL
ENLYFREKKF SVEVHDPRRA SVTRRTFGHS GIAVHTWYAC PALIKSIWAM AISQHQFYLD
RKQSKSKIHA ARSLSEIAID LTETGTLKTS KLANMGSKGK IISGSSGSLL SSGSQESDSS
QTAKKDMLAA LRARQEALEE TLKQRLEELK SICIREAELT GKLPKEYPLD PGEEPPTVRR
KIGTAFKLDE QKILPKGEEE ELERLEREFA IQSQITEAAR RLASDPHVSS KKLKKQRKTS
YLNALKKLQE IENSINEYRV RSGKKPTQRA SLIIEEANIG SEDSSLSDAL VLDDDDPQVT
GTPTFSPVAS PHKGLPPRPP SHSRPPPPQS LDGLRHLHYT RSDYDKSPIK PKMWSESSLD
EPYEKVKKRS SHSSHRRFPS SGSAEAGGSN SLQSSPIRSL PHWNSQSSMP STPDLRTRTP
HYVHSTRSVD ISPTRLHSLS QHFRNRSSSL ESQGKLLASD SDAHPHTLGS PDFFLGPGRS
SNGSDPLDDC SSCTSQSSSE HYYPSGGPPG SNPNYSTLGE DSPSKARQRQ RQRHRSAGHL
GSSNSGSMPN LAAKNGSGGG LGGSGVGGGH HGVYLHSQSQ PSSQYRIKEY PLYVEGSPNP
VVVRSLESDQ EGHYSVKAQF KTSSSYTAGG LYKEAWGGEE GGEGSGRLTP SRSQIVRTPS
LGREGGGGGG GGRAAVSEEL RCWYQRSSGS LKERSHSHSG STSSETGSQQ GTLGHGRGSR
AIATSASPHS QRSMTPSSEH AATPTPPCSP QHILNWQSGG TADCSPTEDV CQSPPQPSSD
A
//
