ID   A0A3B4G814_9CICH        Unreviewed;       454 AA.
AC   A0A3B4G814;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Lipase H {ECO:0000313|Ensembl:ENSPNYP00000019030.1};
DE   SubName: Full=Lipase member H {ECO:0000313|RefSeq:XP_005735474.1};
GN   Name=liph {ECO:0000313|RefSeq:XP_005735474.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000019030.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000019030.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005735474.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR   RefSeq; XP_005735474.1; XM_005735417.1.
DR   AlphaFoldDB; A0A3B4G814; -.
DR   STRING; 303518.ENSPNYP00000019030; -.
DR   Ensembl; ENSPNYT00000019509.1; ENSPNYP00000019030.1; ENSPNYG00000014394.1.
DR   GeneID; 102194543; -.
DR   CTD; 445105; -.
DR   GeneTree; ENSGT00940000156285; -.
DR   OrthoDB; 3428256at2759; -.
DR   Proteomes; UP000261460; Unplaced.
DR   Proteomes; UP000695023; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; LIPASE; 1.
DR   PANTHER; PTHR11610:SF186; LIPASE H-RELATED; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..454
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5041073684"
FT   DOMAIN          38..327
FT                   /note="Lipase"
FT                   /evidence="ECO:0000259|Pfam:PF00151"
FT   ACT_SITE        158
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        182
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   ACT_SITE        251
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT   BINDING         196
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         198
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT   BINDING         201
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
SQ   SEQUENCE   454 AA;  51172 MW;  2AF253A7FD0368AB CRC64;
     MLLWQYLITF LLVTVQICKA EKCDEFTDLN LGHSIIGTSL KVRLLLYTRL SGTCGTLMSH
     TDLSAYPQFN ALKPTTFIIH GYRPTGSPPK WLDKLTERLL VRKDINVIVV DWNYGAATLK
     YWEAVKNTRK VASNITALIN MLQEHGADLS SIHMIGVSLG AHISGFTGAN LKGEIGRITA
     LDPAGPGFKG KNPEDRLDSS DAQFVDALHT DMDLLGFREP LGHIDFYANG GADQPGCPKT
     IFSGQYLKCD HRRSVFLFID SINATCTSRT YPCSSYKDFL DGKCLTCSQF GNAGCPILGY
     DVIKWKDILL EQNQTKAYFK TNEKSPYCMT NYRIDVVIWN KDVQWGYLTV KLHGNGKQAQ
     ATIDHKSLNF KKFTDTELLA TFDKDIQWVE KVSVKFSTGN VLQPKRKLRI LRIRLKNLEP
     KGNKAQGPLC RYDVLLEENK EVTFRPIPCE ESNF
//