ID A0A3B4G987_9CICH Unreviewed; 584 AA.
AC A0A3B4G987;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cdc42-interacting protein 4 homolog {ECO:0000313|Ensembl:ENSPNYP00000018634.1, ECO:0000313|RefSeq:XP_005749998.1};
GN Name=LOC102199521 {ECO:0000313|RefSeq:XP_005749998.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000018634.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000018634.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005749998.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the FNBP1 family.
CC {ECO:0000256|ARBA:ARBA00009426}.
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DR RefSeq; XP_005749998.1; XM_005749941.2.
DR AlphaFoldDB; A0A3B4G987; -.
DR STRING; 303518.ENSPNYP00000018634; -.
DR Ensembl; ENSPNYT00000019097.1; ENSPNYP00000018634.1; ENSPNYG00000014060.1.
DR GeneID; 102199521; -.
DR CTD; 492762; -.
DR GeneTree; ENSGT00950000183047; -.
DR OrthoDB; 2995634at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07653; F-BAR_CIP4-like; 1.
DR CDD; cd11628; HR1_CIP4_FNBP1L; 1.
DR CDD; cd11911; SH3_CIP4-like; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF17; CDC42-INTERACTING PROTEIN 4; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..264
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 388..465
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 522..583
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 331..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 106..203
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 333..349
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 66852 MW; B202EBD063C64166 CRC64;
MDWGTELWDQ YDIIEKHTQS GLELVEKYVK FAKERTEIEQ NYAKQLRNLS KKYNQKRSSK
DEPECRLSSY QAFLDILTEM NDYAGQRELI AENLMMNICI DLTKYLQDLK QERKTYLMDA
KKAQQSLEST YKQLDSSKKR FEREWREAER AAQYAEKTDQ DINATKADVE KAKQQAHMRA
RVADECKNDY AALLQKYNKE QNQFYFSDMP LIFNKLQDLD ERRIQKLAQG YVLFSDTEKH
VMPIIGKCLE GITKAGTNVN EKNDSMIVIE QNKSGFERPG DLEFEDYSQG INRASSDSSL
GTPKVSVDPW KKKPNNFWLF SKRSKLSSPV LAPFSTPPAP SPNGPPSPKF GRDPLSYCLK
EINKTVKPRI SSFRTLRRSP TVTEDFAHLP PEQRRKRLQQ KLDEICKELQ KEVDQSEALG
KMKDVYEKNP QMGDPASLAS QINQTSQNIE RLRGEQSKYE TWLAEAGGRG DTLRYKAHSF
NNNGANDVHS PDGAYSDEST PDPSQAIYAE FDDDFEDEDL AAPIGKCTAM YNFPGASEGT
IAMQEGEVLA VVEEDKGDGW TRVRRNNGDE GYIPTSYVTI TLNK
//
