ID A0A3B4G9C7_9CICH Unreviewed; 882 AA.
AC A0A3B4G9C7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSPNYP00000018248.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000018248.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000018248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3B4G9C7; -.
DR STRING; 303518.ENSPNYP00000018248; -.
DR Ensembl; ENSPNYT00000018701.1; ENSPNYP00000018248.1; ENSPNYG00000013790.1.
DR GeneTree; ENSGT00940000162782; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF418; C-FAMILY ODORANT RECEPTOR OLFCQ19-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 840..863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 613..872
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 882 AA; 98213 MW; 706FCA6FB35A6642 CRC64;
MGGFQVTYIF TGVSVVLLFF PFFFLCFVSS SLSLSCKLER KFHLNEMHKP GDVVLGGLFE
VHYTSVYPER TFTSEPQQPH CTGFDIVGFR NAMTMVFAIE EINKNLNLLP NVTLGYSLYD
NCGALVVALS GALSLASGQE EQFLLQENCS GIPPVLGLVG DHYSTFSIAI SSVLSLYNIP
IVSYFATCSC LSDRQRFPTF FRTIPSDAFQ VRAMIQILKH FGWTWIGLLV SDDDYGLHVA
QSFQSDLAKS GDGCLAYLEI LPWDSDPSEL KRIVHLIKTS TARVVIVFAH EIHLIQLMEE
VAKQNVIGRQ WIASETWTTA SVLQTAHLTP YLRGTLGIAI RRGELPGLRE FLLKIHPDQS
DNGRYNNNLV NQFWEFTFQC RFAPAPAGWL EGGGALCTGQ EHIENVDTEF FDLSNLRPDY
NVYKAVYSLA YALNDMLHCK PGTGPFRGHS CATLQTMEPW QLIHYLQNVN FTTPFGDQVS
FDENGDALPI YDVMNWLHLP DGQIKVQNVG EVKRSGFKSE ELTIDEDKMF WNFESGKPPR
SVCSESCPPG TRMARNKGQP ECCFTCIPCS KGKISKNNNS LECTSCPEDF WSNPQNDHCV
PKKTEFLSYH EPLGICLTTA SLLGTFICAV VLGIFFYHRR TPMVRANNSE LSFLLLVSLK
LCFLCSLLFI GRPRVWTCQL RHAAFGISFV LCVSCILVKT MVVLAVFKAS KPGGGTILKW
FGSMQQRGTV LALTCIQAGI CTAWLVSSSP APHKNMQYQN DKIVYECAVG STIGFAVLLG
YIGVLAVLSF LLAFLARNLP DNFNEARLIT FSMLSFCAVW VAFVPAYVNS PGKYADAVEV
FAILASSFGL LVALFGPKCY IILLKPERNT KKAIMGRLTI NE
//
