ID A0A3B4GB87_9CICH Unreviewed; 1147 AA.
AC A0A3B4GB87;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA repair protein REV1 {ECO:0000256|ARBA:ARBA00020399, ECO:0000256|PIRNR:PIRNR036573};
DE EC=2.7.7.- {ECO:0000256|PIRNR:PIRNR036573};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000018886.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000018886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Deoxycytidyl transferase involved in DNA repair. Transfers a
CC dCMP residue from dCTP to the 3'-end of a DNA primer in a template-
CC dependent reaction. May assist in the first step in the bypass of
CC abasic lesions by the insertion of a nucleotide opposite the lesion.
CC Required for normal induction of mutations by physical and chemical
CC agents. {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945, ECO:0000256|PIRNR:PIRNR036573}.
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DR AlphaFoldDB; A0A3B4GB87; -.
DR STRING; 303518.ENSPNYP00000018886; -.
DR Ensembl; ENSPNYT00000019361.1; ENSPNYP00000018886.1; ENSPNYG00000014241.1.
DR GeneTree; ENSGT00940000156374; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:InterPro.
DR CDD; cd17719; BRCT_Rev1; 1.
DR CDD; cd01701; PolY_Rev1; 1.
DR CDD; cd12145; Rev1_C; 1.
DR CDD; cd19318; Rev1_UBM2; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 6.10.250.1630; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR Gene3D; 1.20.58.1280; DNA repair protein Rev1, C-terminal domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR012112; REV1.
DR InterPro; IPR031991; Rev1_C.
DR InterPro; IPR038401; Rev1_C_sf.
DR InterPro; IPR047346; Rev1_UBM1/2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00817; IMS; 2.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF21704; POLH-Rev1_HhH; 1.
DR Pfam; PF16727; REV1_C; 1.
DR Pfam; PF14377; UBM; 2.
DR PIRSF; PIRSF036573; REV1; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|PIRNR:PIRNR036573};
KW DNA repair {ECO:0000256|PIRNR:PIRNR036573};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|PIRNR:PIRNR036573};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036573};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR036573}.
FT DOMAIN 40..112
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 358..595
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 147..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 126186 MW; 175139F5F2ECB4A9 CRC64;
MSRDGWMRKR ANGGYMAAKV SKLDEQFRLD APREKQKEGA CSSIFTGVAI YVNGYTDPSA
DELRRLMMLH GGQFHVYYSR SKTTHIIATN LPNSKIQELK GEKVIRPEWI TDRSVHCKLI
MFIFHILLNR NLQTSVDVSH SKMNEIQECS KEEPHLAGAS DVKDAPLTNG HTHIVNGALN
SEDLSPQSSS QRANEKRLKP PPPTYQEAIK ATESHLFPKQ LQAPLQVDMI SEKTLSPASR
SLSHSPVRLN GSHHNAFTSD SASLSTNNVT FKSEPPMDES SSSSSNLISE FYSHSRLHQI
STWRSGFSEY VNELHSKRKG AGGASLPGKE RLRKSAAQRS IDTKAGDLGS QVSVKSCILH
VDMDCFFVSV GIRNRPDLKG KPVAVTSNRG QGRGPVRPGA NPQLEMEYYQ KKYTHPQAED
EIHTTPSQES PDSRTNGVEQ DAVALSMAEI ASCSYEARQA GVRNGMFFGK AKQLCPALQS
VPYDFEAYKE VALNMYETLA SYTHDIEALS CDEVLIDGSA LLAEVGASPE DLAKAVRADI
KEKTGCCASV GMGSNILLAR LATRKAKPDG QYFLKSEEVD DFIRDLPVTS LPGVGPVMGR
KLALMGVRSC GDLQQVSLSK LQKKFGPRTG QTLFRFCRGL DDRPVRYEKE RKSVSAEMNY
NIRFTRVDET ECFLTNLSME VQKRLQEASL RGRRVTLKVM VRKIGAPLEP AKYGGHGICD
HLAKTVMLAQ STDSGQLIAA AVIKLFHAMK VEVQDLRGVG IQVQLLEGHQ SATQDCRGLR
GRSIKEMLLG QASSARSNNR DALQEKTTSS TTVPTANSAP YPLSPAEPVP GTSKEQPACR
QTPKHSRTRL NFSIEVPSPS QVDRSVLEAL PAELREQLSP LISHPASPPR PPLATVPALN
YPPVGTLVLQ IPNQPESPGI VLELPNFSQV DPDVFAALPK ELQEELKAAY SRATGIHPQQ
KNPLLQLKQS GAGIGSGRVK RRYKRKNAVS PLKKGASPLK KRPTTNSPAK SLPPTGKSQE
PINNRKTENG PSTSVSKPEI PPAVVKLAAR PPPALAGACD LTDIKTLLRE WVTTITEPME
EDILQVVKYC TDLIEDKDLE KLDLTMKYMK RLMQQSVESV WSMAFDFILD NVQVVLQQTY
GSTLKIA
//
