ID   A0A3B4GBP8_9CICH        Unreviewed;       687 AA.
AC   A0A3B4GBP8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Discs large MAGUK scaffold protein 4 {ECO:0000313|Ensembl:ENSPNYP00000020352.1};
GN   Name=DLG4 {ECO:0000313|Ensembl:ENSPNYP00000020352.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000020352.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000020352.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4GBP8; -.
DR   STRING; 303518.ENSPNYP00000020352; -.
DR   Ensembl; ENSPNYT00000020853.1; ENSPNYP00000020352.1; ENSPNYG00000015386.1.
DR   GeneTree; ENSGT00940000157956; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF10608; MAGUK_N_PEST; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 3.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          36..126
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          134..221
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          286..367
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          401..471
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          497..672
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
SQ   SEQUENCE   687 AA;  76260 MW;  C8CD2631A3DFE83A CRC64;
     LACICVCLQK YRYQDEETPP LEHSPAHLAQ GKSAEMLHMS DKNLGNSGLG FSIAGGTDNP
     HVGDDPSIFI TKIIPGGAAA QDGRLSVNDC ILFVNDVDVR EVTHSQAVEA LKEAGAIVRL
     YVLRRKPAAE KVTEIKLIKG PKGLGFSIAG GVGNQHIPGD NSIYVTKIIE GGAAHKDGRL
     QIGDKILAVN NVCLEDVMHE DAVGALKNTA EVVYLRVAKP NNLFLTNSYN PPDLTSTYSH
     MDTELSHPNY LGSDYPQALT PTSPSRFSPV LHGMMGDDDI PREPRRVLIH RGSTGLGFNI
     VGGEDGEGIF ISFILAGGPA DLSGELHKGD QILSVNGVDL RMATHEQAAA ALKNAGQTVT
     IIAQYRPDEY SRFEAKIHDL REQLMNSSMG SGTTTLRSNP KRGFYIRALF DYDKTADCGF
     LSQALGFKFG DVLHVLDCGD EEWWQARKVS PQNEAEEVGF IPSKHRVERK EWSRVNTKER
     VPSHNYETVT QVEVHYARPI IILGPVKDRI NDDLLSEFPD KFGSCVPHTT RPKREYEVDG
     RDYHFVSSRE QMEKDIQSHR FIEAGQYNSH LYGTSVQSVR EVAEQGKHCI LDVSANAVRR
     LQAAQLHPIA IFVRPKSLEN VLEINTRLTE EQARKGMDRA LKLEQDFLEC FTAVVEGDSF
     EEVYHKVKTV IEEQSGPYIW IPTRERL
//