ID   A0A3B4GC51_9CICH        Unreviewed;       883 AA.
AC   A0A3B4GC51;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=P53-induced death domain-containing protein 1-like {ECO:0000313|Ensembl:ENSPNYP00000020490.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000020490.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000020490.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4GC51; -.
DR   STRING; 303518.ENSPNYP00000020490; -.
DR   Ensembl; ENSPNYT00000020992.1; ENSPNYP00000020490.1; ENSPNYG00000015461.1.
DR   GeneTree; ENSGT00940000166188; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR   GO; GO:0006974; P:DNA damage response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.220.30; -; 2.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR019502; Peptidase_S68_pidd.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR45752; LEUCINE-RICH REPEAT-CONTAINING; 1.
DR   PANTHER; PTHR45752:SF44; P53-INDUCED DEATH DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF10461; Peptidase_S68; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00364; LRR_BAC; 4.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS51450; LRR; 3.
DR   PROSITE; PS51145; ZU5; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          429..558
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          743..829
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   ACT_SITE        418
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT   ACT_SITE        420
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT   ACT_SITE        557
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT   ACT_SITE        559
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT   SITE            419..420
FT                   /note="Cleavage; by autolysis"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
FT   SITE            558..559
FT                   /note="Cleavage; by autolysis"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
SQ   SEQUENCE   883 AA;  97674 MW;  71D093A6A7A8B2C3 CRC64;
     MDTCAPSIST LPSCSYSSSR HTDFSSSSSS PLSLSPPLPP SVELSAVLTD TRLTLDVYRG
     GAAALPLLWE SIPGQLKGLQ YLRLGSEEKV GLDGALDVLS HLTKLRSLAI RGHCLHDSRG
     DPLPGLLTTL PASVSLLSHL VHLDLSFNQL SCLPSCLLSL SMLSSLLLCH NHLSALPSDI
     SQLSSLTYLS LLGNELVSLP PGLGLLKALQ TLDVSNNLLQ ELPDEIGSLE ELVKLELSQN
     KLKQLPESMG SLLSLRELVI YSNDLRLIPL CLNKLPLLKI DVRDNPLGRP PTPPPLSPTP
     GLMLLLLFSF CISSAGCHVF LPGGAELVFP PGCIVTATKL AWAEKRPQRK WVQLEEHEIL
     LSHPLELRPH GVTFLKVCVP YHRTKRKEVV VRTFDGQSWS TLPTELRRGS ESHSSLNHFS
     WFMAVSRPVK DSCSVTPAGG LLVSSADPGV KLHFPPDSTV ETRTITLQVS MSDVQVLCGD
     PQARVSPLLC LSQTPSMHFL QPIKVQIPLP SGVTGTLVDM SCLHLLHGDP TAQTWTDITA
     QVSLYVTHLY AIFYITHFSW YWLWYTTQRC VSGAVRKIYQ RLKQFKVQFL VLQRKTDPSQ
     VLLQCLPSNK VESRMQSLTE QYDGPQPSDL CDLLEGEQFF AGFERGLEIS TDRPDCVGGR
     LCFEFYSSLK NLKEVYICSA QGQKGPVRGQ VSFYRGEIPS NLPEEVARKR KGLDSQWLTT
     LPLRLPVEYP PLNLGDPESG YLTEANLLSI SLQIAQDWRV IGLNLGLSYQ ELERIQYKNR
     DNLGALVLDM LFHWARAQKN EAPGAVSRLV AAMIESGRRD LAEEIEDIVN IGKRKYTESL
     RRVGLEMSPC WAQMADLHLS DLLVYRGPPL SCSVVINCRS AQS
//