ID   A0A3B4GD47_9CICH        Unreviewed;       531 AA.
AC   A0A3B4GD47;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Heat shock factor protein 2 {ECO:0000313|RefSeq:XP_005747847.1};
DE   SubName: Full=Heat shock transcription factor 2 {ECO:0000313|Ensembl:ENSPNYP00000020014.1};
GN   Name=hsf2 {ECO:0000313|RefSeq:XP_005747847.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000020014.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000020014.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005747847.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC       ECO:0000256|RuleBase:RU004020}.
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DR   RefSeq; XP_005747847.1; XM_005747790.1.
DR   AlphaFoldDB; A0A3B4GD47; -.
DR   STRING; 303518.ENSPNYP00000020014; -.
DR   Ensembl; ENSPNYT00000020508.1; ENSPNYP00000020014.1; ENSPNYG00000015148.1.
DR   GeneID; 102192169; -.
DR   CTD; 3298; -.
DR   GeneTree; ENSGT00940000155906; -.
DR   OrthoDB; 1117127at2759; -.
DR   Proteomes; UP000261460; Unplaced.
DR   Proteomes; UP000695023; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000232; HSF_DNA-bd.
DR   InterPro; IPR027725; HSF_fam.
DR   InterPro; IPR010542; Vert_HSTF_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10015:SF185; HEAT SHOCK FACTOR PROTEIN 2; 1.
DR   PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00447; HSF_DNA-bind; 1.
DR   Pfam; PF06546; Vert_HS_TF; 1.
DR   PRINTS; PR00056; HSFDOMAIN.
DR   SMART; SM00415; HSF; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00434; HSF_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW   Stress response {ECO:0000313|RefSeq:XP_005747847.1}.
FT   DOMAIN          49..73
FT                   /note="HSF-type DNA-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00434"
FT   REGION          305..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..326
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..474
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   531 AA;  59197 MW;  06D3D393D119B169 CRC64;
     MKHNSNVPAF LTKLWTLVED TDTNEFICWS QEGNSFLVLD EQRFAKEILP KFFKHNNMAS
     FIRQLNMYGF RKVMHIDTGI VKQERDGPVE FQHPYFRQGQ DDLLENIKRK VSNARPEDNK
     IRQEDLTKIL ASVQSVHSKQ ENIDALLATL KRENESLWRE LSDLRQKHAH QQQLIKKLLH
     FIVTLVQNNR ILNLKRKRPI LMNGNGKKPK FIHQIYDDKV CVEQSSVSSI NGVKGSELSD
     DVIICDLPEN DGEVTSEITE ESQAYEQGDV EIVEVELESC PVLPAETEVC TTIREGLKHT
     EAVSAAAADD GQRSSTLDSS GTTSSALQLN KPSVLSLEDP VKMMDSILNE NGAAISQNIN
     LLGKVELMDY LDSIDCSLED FQAMLYGKQC GIDFDTQEEN VPSKGSTAEV SKGRSEEDNT
     DKQLIQYTTC PLLAFLDGCI PPPDLDLAVD SSSTGSSSTQ HEPSSSSVAS IDAEKSSEIV
     DTSLESKQAH RSSLIRLEPL TEAEASEETL FYLCELSPAG PEADSVQLSR V
//