ID A0A3B4GEY4_9CICH Unreviewed; 549 AA.
AC A0A3B4GEY4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Wiskott-Aldrich syndrome protein-like {ECO:0000313|Ensembl:ENSPNYP00000020689.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000020689.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000020689.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B4GEY4; -.
DR STRING; 303518.ENSPNYP00000020689; -.
DR Ensembl; ENSPNYT00000021191.1; ENSPNYP00000020689.1; ENSPNYG00000015656.1.
DR GeneTree; ENSGT00970000193554; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00132; CRIB; 1.
DR CDD; cd01205; EVH1_WASP-like; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR011026; WAS_C.
DR InterPro; IPR033927; WASPfam_EVH1.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR InterPro; IPR003124; WH2_dom.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00285; PBD; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47912; Wiscott-Aldrich syndrome protein, WASP, C-terminal domain; 2.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS50229; WH1; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 29..138
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 224..237
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 482..499
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 136..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..168
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..412
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..469
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 57497 MW; 1E8BD8D9714957F2 CRC64;
MSRGSKTKTE STQSFLLSPQ ENDKLEELLG RRCASIATAV VQLFMALPNS SSMWSLQHTG
VACFVKDNPQ RSYFIRMFDL KVGSMVWEQE LYNQIVYSAP KQFFHTFPAD DCQVGLNFCD
LHEADLFQTA VQEKINQRNT RQDKKQRPPH TSDRSSLPPL PPEKGPSGPP SFHMATVDIQ
NPDIQSSRYR SVPTPAAASA ATGKGKKDKK KKQKKGLKLS KADIGAPSGF KHVSHVGWDP
NNLDPDLMRL LSQAGISEAE MRDERTSQLI YNVIEQSGGM EAVKREVNRS ATGPPPPPPG
RQGPLPPLPG SSPSAPTPPP QRGRSGPLPP IPGHSQRAGP PPQPPPSRGS LPPPPPSSRS
GPPPPPPSHA PPPPSSRSPH APPPMSSHGA PPPPPPSQRS AGFPPPPVPS TPSRGVGGGG
GGGGGGGGEG GGGGGGGGPP PPPPPPPPPP PQTSVSSDFP PPPPISGGAP RPTSTSVGGG
DSRGALLDQI RLGKKLRNVT DDPNPAPPAS AESGEGIVGA LMMVMQKRSK VIHSSGKYYT
TSDIFLCTL
//
