ID A0A3B4GFP8_9CICH Unreviewed; 766 AA.
AC A0A3B4GFP8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=F-BAR and double SH3 domains protein 2 isoform X2 {ECO:0000313|RefSeq:XP_005720801.1};
DE SubName: Full=FCH and double SH3 domains 2 {ECO:0000313|Ensembl:ENSPNYP00000020316.1};
GN Name=FCHSD2 {ECO:0000313|Ensembl:ENSPNYP00000020316.1};
GN Synonyms=fchsd2 {ECO:0000313|RefSeq:XP_005720801.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000020316.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000020316.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005720801.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005720801.1; XM_005720744.2.
DR AlphaFoldDB; A0A3B4GFP8; -.
DR STRING; 303518.ENSPNYP00000020316; -.
DR Ensembl; ENSPNYT00000020815.1; ENSPNYP00000020316.1; ENSPNYG00000015350.1.
DR GeneID; 102202233; -.
DR CTD; 9873; -.
DR GeneTree; ENSGT00510000046732; -.
DR OrthoDB; 3674259at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR CDD; cd11894; SH3_FCHSD2_2; 1.
DR CDD; cd11761; SH3_FCHSD_1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035556; FCHSD2_SH3_2.
DR InterPro; IPR035460; FCHSD_SH3_1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF11; F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 2; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..283
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 467..528
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 565..627
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 628..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 365..392
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 632..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..680
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 86726 MW; 4A1973197EB1B71C CRC64;
MQPPPRKVKV TQELKNTHTE QMTRLHFKHQ TECDLLEDMR SYSLKKGQLE RDYAQALQKL
ASQYLKRDWP GINPDDQRTD YRNVYAVWRS YLEGTVQVSQ SRLNVCDNYK SQVSEPAKTV
RLYKEQQLKK TIDQLSGIQA ELQESVKELA KAKKKYYDCE QVAHAIREKA DIEAKSKLGL
FQSRISLQKA SVKLKAKRSD CNSKATQARN DYLLTLAAAN AHHDRYYHTD LLHCIQALDG
RIYEHVKDYL VALCRTELEA SQATHNTYQF LLDKSTRIMQ EYNQQLFMQE NPVFHKAHDF
QFQPSECDTS RQLESESGTT EEHSLNKEAR KWATRVAREH KNIIHYKRSL EECESHGLPP
TEQGRLDLEM KIEDTKENMR KAETIKLKAE ARLDLLRQVG VAVDTWLKSA MNQVMEELEN
ERWASYTSHD PSLSGTVDLE REEGEECEEN MEVFDDSSSS PSGTLRNYPL TCKVLYSYKA
SQPDELTIDE QEMLEVIEDG DMEDWVKARN KAGQVGYVPE KYLQFPTSNS LLSMLQSLAT
LDARSHTSSN STEPELHSGC INGDTNMVYV RALYDYEGQA DEELSFSEGA VIRLLSRDTQ
TDDGFWEGEL NGRVGVFPSV LVEDLTENGE TSVGGAGDTQ ISPSLKLPSS LPPLPLYDQP
PISPFTSPET STPPPLPRSP SAALNGEHKL PLPASSHKGP LSAHNQSSGR SPVSPGFAKT
QPPRFTPEGG PGKLRPVRAA PPPPKQHPRR QQEKSDKTEE VEITLV
//
