ID A0A3B4GG65_9CICH Unreviewed; 1378 AA.
AC A0A3B4GG65;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Adhesion G protein-coupled receptor A2 {ECO:0000313|Ensembl:ENSPNYP00000021129.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000021129.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000021129.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR STRING; 303518.ENSPNYP00000021129; -.
DR Ensembl; ENSPNYT00000021638.1; ENSPNYP00000021129.1; ENSPNYG00000015829.1.
DR GeneTree; ENSGT00940000158941; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:1990909; C:Wnt signalosome; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0022009; P:central nervous system vasculogenesis; IEA:Ensembl.
DR GO; GO:1990791; P:dorsal root ganglion development; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF1; ADHESION G PROTEIN-COUPLED RECEPTOR A2; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 763..784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..852
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 917..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1021
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1027..1046
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 249..353
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 336..430
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 757..1052
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1096..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1354..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1378 AA; 149803 MW; 25F66DC6CEE00870 CRC64;
LLQLSSPEVR SSRRTMFAPG VGIPLLPGRL VLMLLLLPRL YQACPGLLAS TSGCSCAEER
PKLHSVQAVG IRVSCSKGEL TELPDPGLLP NRTVTLILSH NKIRVLRNGS FLGLYALDKL
DLKHNLISTI MPGAFQSLSE LRKLDLSNNR IGCLTADMFQ GLTNLTKLNL SGNIISTMNP
GVFEELPSLK LVNFNSDYLT CDCELQWVPN FFRGSPARLG EETLCAYPMS LRGKPLRGLR
EGHLSCDGPL ELHTMSLLPS QRQVVFKGDR LPFHCAAALV DKMTTLHWRH NGQPVTTDPE
MGVQLESSVV HDCTFITSAK TLILYDVHVE ASGEWECVVS TGRGNKSLTV EIVVLENSAS
FCPEDKVVNN RGEFRWPRTL AGITSHQYCL QLRYPSLSVE GGMEQKKASR YCDRTGKWED
GDYSNCHYTN GITRVLHTFI LRPINASNVV TVAHQVRTYT LEAAGFTDSV DVLYMAQIME
KFMEYVTQIK ELLAVMVEMG SNLMQVDEQI LALAQREKRA CSSIVNSLET LAWSQLHSNA
KEFSMMSKNI VMEAHLIQPA HFTGITCTAH QQREVSVGNL GMETSESVHE QQLRVHCSTG
AHNTSLNNFF LKNSVALASV TLPANLFASD AAADCKLQFV AFRTGSFFPL TGNSSTTTEH
SRRRTVNSPV VFVGLDGCSM QNNSDPIWVS LRHLSPGTDA MAAHWSLKGP EKQGGWSQEG
CQLVRSDSNT STMRCSLLSN YAVLQEVPDF PSSPLTVRVL HPVVYACTAV LLLCLFTIII
THILHHSSIC ISRKSWHTLL NTCFHIAMTT AIYAGGISLT SYPVVCQAVG IALHYSSLST
LLWIGVSARV IYKEAVWRMP RQPDGESPVP PTQRPMLRFY LIADGVPLII CGITAAVNVN
DYGDNSPYCW LVRRSSLGSF FVPAGLVVLV TWIYFLCTVF RLRRRGAKEC TGTTLSSPVT
ESHPALAGST SLLSTDSVTG PVHPVMSPED QYSLKTQFSV LVATHFLFVA LWSCAAMAVW
FTGHTSLLFS CLYGIVATVL GGFLVVHHCF RRQDVQTSWL ACCPGYQRPH PMSTYTHTCT
TGSGVQTSEQ GSQLFINCHP PGDSHNSSSA RSSSTPSGIS SVGPGPCKLT NLLQATQDNS
NGTSRAPTGN NTSTSTDNIT KPTNNVLPTI NSAAPGQPQR RKASSRTKQG SSQYYHRGEG
RGHYRLKALR AAGGGGSLGA LGPIGLDHLS SSHAVYKQAT SENGSIHHSL SENQASVLTN
GKRVGESVAT SPSEGSDGGS SGSRKPFPLL PSMASRVAMQ NAQRRCASRD NLKVAASAET
KRCSYPLNGD TATVPGAAGQ NGNLKNSVLE LEQDMSGTDQ SQSSVGMKSG LWKSETTV
//
