ID A0A3B4GHV8_9CICH Unreviewed; 629 AA.
AC A0A3B4GHV8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Elongation factor for RNA polymerase II {ECO:0000313|Ensembl:ENSPNYP00000021714.1};
DE SubName: Full=RNA polymerase II elongation factor ELL {ECO:0000313|RefSeq:XP_005727140.1};
GN Name=ell {ECO:0000313|RefSeq:XP_005727140.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000021714.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000021714.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005727140.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ELL/occludin family.
CC {ECO:0000256|ARBA:ARBA00009171, ECO:0000256|PROSITE-ProRule:PRU01324}.
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DR RefSeq; XP_005727140.1; XM_005727083.1.
DR AlphaFoldDB; A0A3B4GHV8; -.
DR STRING; 303518.ENSPNYP00000021714; -.
DR Ensembl; ENSPNYT00000022242.1; ENSPNYP00000021714.1; ENSPNYG00000016397.1.
DR GeneID; 102207005; -.
DR CTD; 8178; -.
DR GeneTree; ENSGT00940000155914; -.
DR OrthoDB; 2910197at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0008023; C:transcription elongation factor complex; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.140.340; -; 1.
DR Gene3D; 1.10.10.2670; E3 ubiquitin-protein ligase; 1.
DR InterPro; IPR042065; E3_ELL-like.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR019464; ELL_N.
DR InterPro; IPR010844; Occludin_ELL.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23288; OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR PANTHER; PTHR23288:SF9; RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR Pfam; PF10390; ELL; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR SUPFAM; SSF144292; occludin/ELL-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|RefSeq:XP_005727140.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein biosynthesis {ECO:0000313|RefSeq:XP_005727140.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 519..629
FT /note="OCEL"
FT /evidence="ECO:0000259|PROSITE:PS51980"
FT REGION 283..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 70181 MW; B11F713444C0ADDC CRC64;
MAALKEEQCY GLSCGRVSNG SNVSVFHVKL TDSALKAFEA YQSSRVLSSS PLIRFNGNQG
KISIPRSENS SELQTFTFYL SNVGRDNPQG SFDCIQQYIT SEGSIQLDCL GGIQDKITVC
ATDDSYQKAK ESMAQVEEET RSRSAIVIKP GGRYVGKKVQ IRKPAPGLSD VAPLRRTSRP
VIISSSTLKK SATQHRPLRE RLVHLLALKP YKKPELILRL QKDGLSPLDK DSLDSHLQQV
ANLNGRENTF TLKDFLYKEI QKDWPGYTEG DQQLLKRILF RKQAQNSSAP PPESPPKELA
SCSPSQKRPA ADFIDPLANK KPRISHLASK AATPPVNGKI SSSNGRGDAG SAQSVVVGSA
PDGGTPSGSQ QLPMLDIPRP FEALSDVSND SSNNGRDCDS QESAVPERFS QPPSLPQTSS
PRHTILEAPR DKSSSSLNTK SKKKSKKHKD KEKSKDKEKV REKEQENERK SRDECVPEPN
RACETSLGNL KSNSIPHRST DLNGMCNSTS IPSSSPEVAD YLLKYTVISS PEQRQRYKND
FNAEYSEYRG LYARIEGITR QFTVLDNELK QLQHGTDKYK TVHNQILQEY RKIKKTNPNY
SQEKNRCEYL HNKLAHIKKL IAEYDQQQL
//
