ID   A0A3B4GJN7_9CICH        Unreviewed;       748 AA.
AC   A0A3B4GJN7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Exostosin-1b {ECO:0000313|Ensembl:ENSPNYP00000023175.1, ECO:0000313|RefSeq:XP_005748718.1};
GN   Name=EXT1 {ECO:0000313|Ensembl:ENSPNYP00000023175.1};
GN   Synonyms=LOC102196503 {ECO:0000313|RefSeq:XP_005748718.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000023175.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000023175.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005748718.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004648}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC       {ECO:0000256|ARBA:ARBA00010271}.
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DR   RefSeq; XP_005748718.1; XM_005748661.1.
DR   AlphaFoldDB; A0A3B4GJN7; -.
DR   STRING; 303518.ENSPNYP00000023175; -.
DR   Ensembl; ENSPNYT00000023742.1; ENSPNYP00000023175.1; ENSPNYG00000017483.1.
DR   GeneID; 102196503; -.
DR   CTD; 497280; -.
DR   GeneTree; ENSGT00940000155321; -.
DR   OrthoDB; 1220028at2759; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000261460; Unplaced.
DR   Proteomes; UP000695023; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR004263; Exostosin.
DR   InterPro; IPR040911; Exostosin_GT47.
DR   InterPro; IPR015338; GT64.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR   PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR   Pfam; PF03016; Exostosin; 1.
DR   Pfam; PF09258; Glyco_transf_64; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          113..398
FT                   /note="Exostosin GT47"
FT                   /evidence="ECO:0000259|Pfam:PF03016"
FT   DOMAIN          482..731
FT                   /note="Glycosyl transferase 64"
FT                   /evidence="ECO:0000259|Pfam:PF09258"
FT   REGION          41..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   748 AA;  86375 MW;  0B4766656115F71A CRC64;
     MERCSQGHMQ AKKRYLILLS AGACLVLLFY LGGVQLPAAS RSRHDRSRNG HRPEQPWPHF
     SDPLHLFLPW DQTDTEDYNL HISPRQKRDI NTSVYKGKRC RMDSCFDFSL CRKNGFKVYV
     YPQQKGEKIS ESYQNILSTI EGSRFYTSDP GQACLFVLSL DTLDRDQLSP QYVHNLKTKV
     QNLPLWNDGR NHLIFNLYSG TWPDYTEDLG FDIGQAMLAK ASISTENFRP NFDVSIPLFS
     KEHPRTGGER GYLKYNSIPP FRKYMLVFKG KRYLTGIGSD TRNALYHVHN AEDVVLLTTC
     KHGKDWQKHK DARCDKDNAE YDKYDYKEML HNSTFCLVPR GRRLGSFRFL EALQAACVPV
     MLSNGWELPF SEIIDWNTAA VIGDERLLLQ IPTTVRSIHQ DKILSLRQQT QLLWEAYFSS
     VEKIVLTTLE IIQDRVLEHA SRSSLMWNSH PGGLFALPQY SGYLGDFPFY YDTLGIRPYP
     KFTAVIHAVS PLVSQSQPIL KLLAAVAKSQ YCAQIIVLWN CDKPLPAKHR WPATSVPVIV
     IEGENKVMSS RFLPYEIIVT DAVLSLDEDT VLSTTEVDFA FTVWQSFPER IVGYPARSHF
     WDSNKERWGY TSKWTNDYSM VLTGAAIYHR YYHFLYTNYL PTSLKSMVDQ LANCEDILMN
     FLVSAVTKLP PIKVTQKKQY KETMMGQSSR ASRWADPDHF AQRQTCMNKF ASWFGAMPLV
     HSQMRLDPVL FKDQVSILRK KYRDIERL
//