ID A0A3B4GKF5_9CICH Unreviewed; 1154 AA.
AC A0A3B4GKF5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Protocadherin 12 {ECO:0000313|Ensembl:ENSPNYP00000021891.1};
GN Name=PCDH12 {ECO:0000313|Ensembl:ENSPNYP00000021891.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000021891.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000021891.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4GKF5; -.
DR Ensembl; ENSPNYT00000022424.1; ENSPNYP00000021891.1; ENSPNYG00000016456.1.
DR GeneTree; ENSGT00940000160403; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF42; PROTOCADHERIN-12; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1154
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017197331"
FT TRANSMEM 711..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..129
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 130..238
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 239..346
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 352..457
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 458..562
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 611..705
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 751..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 126143 MW; 1298DB00C720441F CRC64;
MLLALLLVAS LCSKTLSSHC SSTTIQYQVS EEQPAGTRVG CLADDLRQRD EGGSLEDFQV
VEQGKALPFS VTTRDGVVST QGRLDREELC RGTDLCEVAF SVLYRKRGAV KCLRVHVKVM
DLNDHSPSFP NTLQEVEISE TASLGKRIPL DWAVDPDAGS NSLQTYSLSV NQHFDLDVTV
GPGGTKQAEL VVVKELDREI QASFDLTLVA WDKGNPPRSG STLVRVSIQD SNDNSPTFED
SNPTVSLPED TALGTTVIKL KATDPDQGAN GEVEYSFSKH THPEVQRLFY VDPQTGEVSI
RAPLDYEAQS SYEVIVQASD HGPNAIPSYC RLHVKLIDIN DNAPRIRLTW TPASSQVITV
LEGAPEDTLL AVVTVSDADS GRNGNVTAQI QQGSGPFRLK KMHGNDYMIV TSGSLDREKV
MQYNITLFAR DSGNPLLSYV EHLPVYVLDE NDNAPVFSTP IYRASFKENN MTGYHILKVE
AHDEDLELSG KVSYSIVEET KTQTFSIHPK TGVISVQQPL DYEAFKNYSF IVEAVDHGHP
PLTSTARVHI DIEDVNDNFP VIKEPKPRKG VASLSVPVDA YRGEIVTELG NAIKEEATNV
ATDHSVREGL GFLASTIKAE DQDTGLNGKL QYLITDGNPS ELFWLNNTSG QLFVNTTNAT
ELIGKTFKVD ITVSDMGTPR LATKATLEVT FINLKDHLKN SSPGNRGQLS FTMMMAICLG
ATCLLLLLAI ALVTTFCRPE KRDNRAYNCR QAESTYTRHP RRPQKNIRKS DIQLIPVIRG
RKEDLPEDDG EAQPLTPPPA SDDQQIESHY SLMPSVMNAS FHSQGYLEED VTQPNTHHCR
TLRKPGNIEL DGTLPSSPAT SYRTLHKSRN TSSSSSETVS QYSSASVATL RRPKTSDGHG
ARDAAHRQIL RNLVRLSMAA FGDSIELSSA SPEVQQISQL LSLLHQGQLQ PRTNFRGNKY
SHRNGRSDCS DWQSTKDSGH GESEAGDVDW EPGRDSPIDP QLEEGLSNLL NNPAIASLSA
DDVFSEVSDP SWMARLSLPL TSDYHDNVFV PNSPPSPESE TLPRDGLESS SFSTFGKTPE
KDGPLGGALL SEVSTLFEML MTQKADAHPG PRPDVLYRLS AAYRRSLGLD GGAAGNAAKN
SVRSGPSAPS GLCQ
//
