ID   A0A3B4GMY4_9CICH        Unreviewed;       184 AA.
AC   A0A3B4GMY4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Vacuolar protein sorting-associated protein 29 {ECO:0000256|ARBA:ARBA00017767, ECO:0000256|RuleBase:RU362040};
DE   AltName: Full=Vesicle protein sorting 29 {ECO:0000256|ARBA:ARBA00031913, ECO:0000256|RuleBase:RU362040};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000022726.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000022726.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC       (CSC). The CSC is believed to be the core functional component of
CC       retromer or respective retromer complex variants acting to prevent
CC       missorting of selected transmembrane cargo proteins into the lysosomal
CC       degradation pathway. {ECO:0000256|RuleBase:RU362040}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}.
CC   -!- SIMILARITY: Belongs to the VPS29 family.
CC       {ECO:0000256|ARBA:ARBA00005945, ECO:0000256|RuleBase:RU362040}.
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DR   AlphaFoldDB; A0A3B4GMY4; -.
DR   STRING; 303518.ENSPNYP00000022726; -.
DR   Ensembl; ENSPNYT00000023286.1; ENSPNYP00000022726.1; ENSPNYG00000017155.1.
DR   GeneTree; ENSGT00390000012669; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR   CDD; cd07394; MPP_Vps29; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR024654; Calcineurin-like_PHP_lpxH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR000979; Phosphodiesterase_MJ0936/Vps29.
DR   InterPro; IPR028661; Vps29.
DR   NCBIfam; TIGR00040; yfcE; 1.
DR   PANTHER; PTHR11124:SF12; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 29; 1.
DR   PANTHER; PTHR11124; VACUOLAR SORTING PROTEIN VPS29; 1.
DR   Pfam; PF12850; Metallophos_2; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU362040};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362040}.
FT   DOMAIN          5..158
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF12850"
SQ   SEQUENCE   184 AA;  20566 MW;  DB89936A53977CBE CRC64;
     MPGLVLVLGD LHIPHRCNTL PAKFKKLLVP GKIQHILCTG NLCTKESYDY LKTLAGDVHI
     VRGDFDENLN YPEQKVVTVG QFKIGLIHGH QVIPWGDMAS LALLQRQLDV DILISGHTHK
     FEAFENENKF YINPGSATGA YSALESNIIP SFVLMDIQAS TVVTYVYQLI GDDVKVERIE
     YKKS
//