ID   A0A3B4GN31_9CICH        Unreviewed;      1533 AA.
AC   A0A3B4GN31;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=RPTOR independent companion of MTOR complex 2 {ECO:0000313|Ensembl:ENSPNYP00000024410.1};
GN   Name=RICTOR {ECO:0000313|Ensembl:ENSPNYP00000024410.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000024410.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000024410.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RICTOR family.
CC       {ECO:0000256|ARBA:ARBA00008878}.
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DR   STRING; 303518.ENSPNYP00000024410; -.
DR   Ensembl; ENSPNYT00000025011.1; ENSPNYP00000024410.1; ENSPNYG00000018378.1.
DR   GeneTree; ENSGT00390000002096; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR028268; Pianissimo_fam.
DR   InterPro; IPR028267; Pianissimo_N.
DR   InterPro; IPR029453; Rictor_IV.
DR   InterPro; IPR029451; RICTOR_M.
DR   InterPro; IPR029259; RICTOR_phospho.
DR   InterPro; IPR029452; RICTOR_V.
DR   PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR   PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR   Pfam; PF14663; RasGEF_N_2; 1.
DR   Pfam; PF14666; RICTOR_M; 1.
DR   Pfam; PF14664; RICTOR_N; 1.
DR   Pfam; PF14665; RICTOR_phospho; 1.
DR   Pfam; PF14668; RICTOR_V; 1.
DR   SMART; SM01303; RasGEF_N_2; 1.
DR   SMART; SM01307; RICTOR_M; 1.
DR   SMART; SM01308; RICTOR_N; 1.
DR   SMART; SM01309; RICTOR_phospho; 1.
DR   SMART; SM01310; RICTOR_V; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
FT   DOMAIN          1..287
FT                   /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01308"
FT   DOMAIN          369..588
FT                   /note="Rapamycin-insensitive companion of mTOR middle"
FT                   /evidence="ECO:0000259|SMART:SM01307"
FT   DOMAIN          766..838
FT                   /note="Rapamycin-insensitive companion of mTOR"
FT                   /evidence="ECO:0000259|SMART:SM01310"
FT   REGION          865..889
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          943..1074
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1091..1128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1409..1428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        943..989
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1028..1059
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1533 AA;  170734 MW;  1794E3550EEB0919 CRC64;
     IITVNAMLFP TSIANSLIAV GTDGLQERDR MVRAAIAIVC ELALKNPEVV AKRGGLSTIL
     KSVIDCQLSR INEALITTIL HLLNHPRTRQ YVRVDVELEQ ILAPFTDFHY RHNADTAEGQ
     LKEDREARFL SSRMAIVAAF RSWSGIINLC KAGNSGIQSL IGLLCIPNME VRKGLLEVLY
     EIFRLPVPIV TQDFTEALLS VDPARFQDTW RLSDGFVAAE AKVILPHRAR SRPDLMDNYL
     AFVLSAFISS GLLEGLVEVV TSSDDQLAVR ATILLGDLLH MANTILPHSH SHHLHCLPTL
     INMAASFDIP QEKRLRASAA VNNLKRFHEK KKKGLKPHSL YLDHIIRKSV SSHNRRDSRV
     HKDIYVIKDT EEALMMNLRD SQILNHKQNL EWNWLLIATI LKWPNVNLRN NKDEQMHKFV
     RRLLYFYKPS SKLYAGLALD HLKARQLTVV GCQFVEFLMD SDEDGQGYLE DLVKDMVSWL
     SSSSGMKPER CLQSNGLLTT LSQHYFLFLG TLSAHPQGVK LLEKCGLFQC LLNLCSVKNQ
     DAVLKLAVST LDYSRDGLAR VILSKILTAS TDTCRLYATK HLRVLLRAGV EFFSSWGMEL
     LVTQLHDHNK AVSMEALDIL DEACEDKANL HALIQLKPAV SHLGDKGLLL LLRFLSIPKG
     FSYLNERGYV SKQLDKWQKE YNLKYVDQIE EQLNEALTTY RKPVDGDNYV RRSNQRLQRP
     NVYLPVHLYG QLVHDKTGCH LLEAQSVVPD LSYTIRSPML DTWEGIKQLK AALWALGNIG
     SSNWGLNLLQ EENVIPDILA LAQHCEVLSV RGTCVYVLGV ITKTKQGCEV LKQFGWDAVR
     HSRRTLWPVT PDEVDTQLTS ELSSVPSTLS LNSESTSSRH NSESESQPNM YILDDDKCDV
     LDQSDETSLY LHSKPVKDRS PFTILASTRF VRTRFLNSLS LPSKKLRSTS DPKTPSGSRT
     PTELKTGSMR RNRTVTEPSV YSPNQGDFTP IFNGRGMPKS PTVSLETSFV GTRGGSEDGG
     NVGGGGGGTQ FKSRSQSFNT DTTTSGISSM SSSPSRETVG NPEHPEAEPD SSDCVSLNTV
     VSAKTVKTLS SLTPQSQTNH MSTSKSSTVS LVPPGSSHTL PRRAQSLKSP SVTTIKSLAD
     CSFMYTSPRD ALGYATLKRL QQQRIHPSLS HSEALASPAK DVLFTDTITM KSGSLDSRLT
     PRSKKKFPLS VLLPNIFSHL FPMFLKALSF ASLDKEELLS PINQSTLHRC SSVRSMVSSV
     TFGCNDDYIG LALPMDIHDM FHIRDSAYFQ QRISPPSEER KRFLFGDRPA LPVLKQQFSI
     SELIVHRGDT PNHMVGSEET GLQVHTEENC LYCVGAIVLG YPTQPLINST HSRTDFVDFP
     SWGGQSGHRL EVMPQSKFSG VSGCSDAAVS QGSVSGTPTP GGKAISEDGP ASRVLLRKEV
     LRLIINLSSS VGTKGHETGL LTIKEKFSYA FDDICLYSEV SHLLSHCAFR LTSRRFIQEL
     FQDVQFMPMF EEAEAILTKQ PKPVEEDTLR SFL
//