ID   A0A3B4GNB9_9CICH        Unreviewed;       509 AA.
AC   A0A3B4GNB9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=DNA polymerase epsilon subunit {ECO:0000256|PIRNR:PIRNR000799};
DE   AltName: Full=DNA polymerase II subunit 2 {ECO:0000256|PIRNR:PIRNR000799};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000022851.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000022851.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Participates in DNA repair and in chromosomal DNA
CC       replication. {ECO:0000256|PIRNR:PIRNR000799}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR000799}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000256|ARBA:ARBA00009560, ECO:0000256|PIRNR:PIRNR000799}.
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DR   AlphaFoldDB; A0A3B4GNB9; -.
DR   STRING; 303518.ENSPNYP00000022851; -.
DR   Ensembl; ENSPNYT00000023412.1; ENSPNYP00000022851.1; ENSPNYG00000017215.1.
DR   GeneTree; ENSGT00390000012435; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.60.21.60; -; 1.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR024639; DNA_pol_e_bsu_N.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708:SF0; DNA POLYMERASE EPSILON SUBUNIT 2; 1.
DR   PANTHER; PTHR12708; DNA POLYMERASE EPSILON SUBUNIT B; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
DR   Pfam; PF12213; Dpoe2NT; 1.
DR   PIRSF; PIRSF000799; DNA_pol_eps_2; 2.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|PIRNR:PIRNR000799};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR000799};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000799}.
FT   DOMAIN          4..75
FT                   /note="DNA polymerase epsilon subunit B N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12213"
FT   DOMAIN          263..463
FT                   /note="DNA polymerase alpha/delta/epsilon subunit B"
FT                   /evidence="ECO:0000259|Pfam:PF04042"
SQ   SEQUENCE   509 AA;  57258 MW;  C532A1308E1B5DD3 CRC64;
     MDVARRIKTK VSSGFKMRGL ILRPEASRYL VEVLESVSHS ELDDVIERVL DAVEKQPLSS
     SMIELSVVES AVQDCTQTCD ETIDNVFNII GAFDVPRYIY SVERKKFVPI SMTSHPAPSL
     CGLAREKAEL FRERYTILQQ RTHRHELFTP PAIGAAVEEG QNKFQLKTVE ALLGSTAKLG
     EVIVLGMITQ LKEVSDPDKY KRLCWYEDSV FHVNGFGFPP TEPSSATRAY YGNINFFGGP
     SATSVKTSAK LKQLEEENED AMFVIVSDVW LDSVEVMEKL NIMFSGYAAM PPTCFIFCGN
     FSSAPYGKTQ LKSLKESLKA LADAICSYPS IHSSSRFVFV PGPEDPGPGT ILPRPPLADH
     ITEEFRQRVP FSVFTTNPCR IQYCSHEIII IREDLVNKMC RNCVRLPNNN LDIPNHFVRT
     ILSQGHLTPL PLYVSPVFWA YDFSLRVYPV PDVIVFADKY DPFSITNTDC LCVNPGSFPK
     SGFGFKVYYP SNRTVEDRWG TLVSDKVKR
//