ID   A0A3B4GP63_9CICH        Unreviewed;       383 AA.
AC   A0A3B4GP63;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000023131.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000023131.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000256|RuleBase:RU369013}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457,
CC       ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}. Golgi
CC       apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane
CC       protein {ECO:0000256|RuleBase:RU369013}.
CC   -!- SIMILARITY: Belongs to the ERGIC family.
CC       {ECO:0000256|ARBA:ARBA00005648, ECO:0000256|RuleBase:RU369013}.
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DR   AlphaFoldDB; A0A3B4GP63; -.
DR   STRING; 303518.ENSPNYP00000023131; -.
DR   Ensembl; ENSPNYT00000023698.1; ENSPNYP00000023131.1; ENSPNYG00000017446.1.
DR   GeneTree; ENSGT00530000063113; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-UniRule.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1.
DR   PANTHER; PTHR10984:SF30; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013};
KW   ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW   ECO:0000256|RuleBase:RU369013};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU369013};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369013};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU369013};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU369013}; Transport {ECO:0000256|RuleBase:RU369013}.
FT   TRANSMEM        36..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369013"
FT   TRANSMEM        313..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369013"
FT   DOMAIN          13..99
FT                   /note="Endoplasmic reticulum vesicle transporter N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13850"
FT   DOMAIN          167..330
FT                   /note="Endoplasmic reticulum vesicle transporter C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07970"
SQ   SEQUENCE   383 AA;  43223 MW;  DA8D63051B56F870 CRC64;
     MRRLSRKKAL SLVKELDAFP KVSESYVETS ASGGTVSLLA FSAMALLAVL EFFVYRETWM
     KYEYSVDKDF SSKLRINIDI TVAMKCQHVG ADILDLAETM ITSNGLQYEP VIFELTPQQR
     LWQRTLLLIQ NRLREEHALQ EVLYKTLLKG APTALPPRSD ASMEPLNACR IHGHVYVNKV
     AGNLHITVGK PIHHPQGHAH IAAFVSHETY NFSHRIDHLS FGEELPGVIN PLDGTEKITY
     NNNQMFQYFI TVVPTKLNTY KISADTHQFS VTERERLINH AAGSHGVSGI FVKYDTSSLM
     VTVSEQHMPL WQFLVRLCGI IGGIFSTTGM LHGLVGFCFD VICCRFKLGL YRPGEVLNQD
     AQLHQMNNLN HHHTPLLADN PPR
//