ID   A0A3B4GPM1_9CICH        Unreviewed;       987 AA.
AC   A0A3B4GPM1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Semaphorin 6A {ECO:0000313|Ensembl:ENSPNYP00000023281.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000023281.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000023281.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   AlphaFoldDB; A0A3B4GPM1; -.
DR   STRING; 303518.ENSPNYP00000023281; -.
DR   Ensembl; ENSPNYT00000023850.1; ENSPNYP00000023281.1; ENSPNYG00000017551.1.
DR   GeneTree; ENSGT00940000156565; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   PANTHER; PTHR11036:SF12; SEMAPHORIN-6A; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..987
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017191393"
FT   TRANSMEM        627..652
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..511
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   REGION          346..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          734..756
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          890..987
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        896..914
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        930..953
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   987 AA;  110095 MW;  DE528F1A7323ED66 CRC64;
     MRSEALLLYF TLLQIAGAGF PEDSEPISIS HGNYTKQYPA FVGHKPGRNN TQRHKLDIQL
     IMIMNRTLYI AARDHIYTVD TDTANSEEIF FSKKMTWKSR QGDVDTCRMK GKHKDECHNF
     IKVLLQQNED TLFVCGTNAF NPSCRTYKID TLEAQGEEIS GMARCPYDAK HANVALFADG
     KLYSATVTDF LAIDAVIYRS LGDSPTLRTV KHDSKWLKEP YFVQAVNYGD FIYFFFREIA
     MEYNTMGKVV FPRVARVCKN DRGGSPRVLE KQWTSFLKSR LNCSIPGDSH FYFNILQAVT
     DVIHINGRDV VMATFSTPYN SIPGSAVCAY DMAEVANTFT GRFKEQKSPD STWTPFPEEK
     VPKPRPGNCA GTPPMERYKV SNEFPDDTLN FIKMHPLMDE AVPSIANRPW FLKTMVRYRL
     TRIVVDNEAG PYKNHTVVFL GSEKGIILKF LAKMNNGFLN ESLFLEELSV YNPDKCSIDG
     VEDKRIVGIQ IDSKSHALWV AFTSCVVKVP LSRCERHGRC KKSCIASRDP YCGWVPEGAC
     RQVVGNTKSA FEQDVEHGNT DGLGDCQSKQ ALFTLIFPPS LCTPTSTTNT TTPTTIPLFF
     VNSISLFSRL SVCVIRESYQ KGRDQLVPVT LLAIAVILAF AMGAIFSGII VYCVCDHRRR
     DMDLTGRKEK DTHHLHSRRG SMNSVTKLTG LFETQAKEGR PEAILTPLMH NGRLTPNGKM
     LIKADQHHLD LAALPTPEST PMQPRRKPSR GSREWERNQN LINACTKDMP PMGSPVISTD
     LPLRASPGHI PSVVPHLQQH QQSYQHEYVE QPHHSDMSMG HGVLDDQGAT LEYKTSKSPC
     HNLNMADPDV VLPPRVPQRE ASLTIPPAVP QMGKRLEVHS SVYGLRKGSA SGACGSSALK
     KHNTNSSNSS HLARHHSFNR VETPPPAPQR VDSIQMTAQG ISLSRQPGMS SYGSLPRTGV
     KYLKPDVPPK PSVVSLSTKV KSSDSGT
//