ID A0A3B4GS05_9CICH Unreviewed; 1160 AA.
AC A0A3B4GS05;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Insulin receptor substrate 1-B-like {ECO:0000313|Ensembl:ENSPNYP00000024091.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000024091.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000024091.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4GS05; -.
DR STRING; 303518.ENSPNYP00000024091; -.
DR Ensembl; ENSPNYT00000024687.1; ENSPNYP00000024091.1; ENSPNYG00000018212.1.
DR GeneTree; ENSGT00940000166953; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF10; INSULIN RECEPTOR SUBSTRATE 1-B; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 13..115
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 137..241
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 242..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 968..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1160 AA; 124688 MW; 345FC7E80F88F3E9 CRC64;
MENQAAEPQN YEDVQKSGYL RKHKSMHRRF FVLRAASEHG PARLEYYENE KKFRSKSPVP
KKVLNLETCF NINKRADSKN KHMIVLYTRS ESFAIAADSE EVQNEWYQAM LDLQGNKTPE
DYGSSGECSS PSPVPTFKEV WQVKVWPKGL GHARNLVGIY RLCLTDKTVN FVKLNSDVAS
VVLQLMNVRR CGHSENFFFI EVGRSAITGP GEFWMQVDDS VVAQNMHETL LEAMKALSEE
FRQRSKSQSV GTSCGGGTAS NPISVPSRRH HPNLPPSQVG FSRRARTETP GTGGSSTSTS
PTSRHGFPRA RTASIGARSE ESGASAKGTW ASSSPSLNGS CSTTPTLRPK PTRAPTPAKI
TLSLARYTPN PAPSPAPSLS SSSGHGSECG LVGAAVGGMT ICSYPRVSQR VSVSGSPSDY
GSSDEYGSSP GEHSLLLPSL SGHHVHGEGS SSYIVMGQRE SLLGSHHRSK GRRILRRSSS
RESEAERRLL SKRASLPVAS HERLTPHRKD EDDEDDKEYA IMSQSANTQR ADLHHDSGRL
RVGGGQLVGE NRKRSDKSGE EVDRGAAVDS GYMSMLPGVT SPPVSLSLSI GISDSGTKPG
ADDEYMAMTP NNSVSPPQHI RQPSSEGYMV MSPNSSSSTD LHGLGMWDSR GNMESRAASD
YMNISPVSSR SACSTPPSHP EQHQLQPKMF NSYFSLPRAY QHTLYTRFED DLNKGEGKKD
GSGHDSAGRG GGVGYSKRNK IAMGAAGSCQ LSMSSSSFSS SSASSESLED KSISAGRGLS
LLRTGAEYKS AGTSTKDGRH HQKRASSSKS PKQQRRGRPL SVSSDITKAN TLPRVKENLP
PSVSQNVGEY VSIVFKEDSK YGEGRCAGSE RPVIHGTLRP VNQPLLCHDN PANLPRSFSA
PLSTSAEYVS MDLGKSSTPV THVRSTFSTQ QGPPAVAPKA RHEHGTSSPL AAEGNVGYRT
KIKTAAALTE VPPPFTESKA SDPSTSARPA IHSGQPLPVE QETGLGFSPV KSFQSPERSS
RLVRGDQQGR LSHCPETFNS PPSLPRHASS STSLFPEGSQ AVGHRHGLDC SLWESGQAAS
MSATPPPQAS TSSGEQGLNY IDLDLAIKES PQAGVEHTSS AYNMGGSAMG SSAGSSLNTY
ASIDFYKSEE LRAHQNSRKD
//
