ID A0A3B4GUF8_9CICH Unreviewed; 1222 AA.
AC A0A3B4GUF8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000025058.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000025058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B4GUF8; -.
DR STRING; 303518.ENSPNYP00000025058; -.
DR Ensembl; ENSPNYT00000025674.1; ENSPNYP00000025058.1; ENSPNYG00000018860.1.
DR GeneTree; ENSGT00940000166212; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF448; PROTEIN JAGGED-1; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00214; VWC; 1.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1066..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..228
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 229..262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 373..409
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 411..447
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 449..484
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 486..522
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 524..560
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 590..626
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 628..664
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 666..702
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 704..740
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 743..779
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 781..817
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 819..855
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1185..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 186..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 199..211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 219..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 252..261
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 361..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 399..408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 437..446
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 453..463
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 474..483
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 512..521
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 550..559
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 616..625
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 654..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 692..701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 730..739
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 769..778
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 807..816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 845..854
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1222 AA; 133875 MW; B441E1F3C6A1F094 CRC64;
IFRGMLLVRF GKPLIPLHSL FCLQQVSEGS GQFELQILSM RNANGELLSG VCCDGARSGA
DRKCTRDECN TFFKVCLKEY QSRVSAAGPC SFGMGSTPVL GGNTFSFKSS VRNDKSRIVL
PFSFAWPRSY TLIVEALDFN NETSGVDGRL IEKASHSGMI NPSPQWQKLT HNGPVAQFEY
QIRVSCDEHY YGFGCNKFCR PRDEFFGHYT CDNNGNKTCL EGWSGPDCNT AICRQGCSTE
HGSCKEPGGC KCLYGWQGQY CDKCIPHPGC VHGTCKEPWQ CLCDINWGGH LCDKDLNYCG
THQPCLNRGT CINTGPDKYQ CTCAEGYSGA NCERAEHACL SNPCSNGGSC SETSQGYECQ
CAPGWTGPSC TINVDDCLPN PCNHGGTCQD LVNSYKCHCP SQWTGKTCLI DANECDSKPC
VNANSCRNLI GGYFCECLPG WTGQNCDINI NDCKDQCQNG GTCKDLVNGY RCACPPGFAG
EHCERDIDEC ASSPCLNGGR CQDEVNGFQC LCLTGFSGNL CQLDIDYCLP NPCQNGAVCF
NLATDYYCAC PEDYEGKNCS HLKDHCRTTT CKVIDSCTVA VASNSTPGGE RYISSNVCGP
HGRCQSQAGG QFSCECQEGF RGTYCHENIN DCESNPCRNG GTCIDKVSVY QCICGDGWEG
DHCEINIDDC STNPCHNGGT CRDLVTDFFC ECKNGWKGKT CHSRESQCDE ATCNNGGTCY
DEGDTFQCKC SPGWEGTTCN IAKNSSCLPN PCENGGTCVV TGDSFTCVCK EGWEGPTCTQ
NTNDCSPHPC YNSGTCVDGD NWYRCECAPG FAGPDCRINI NECQSSPCAL GSTCVDEING
YRCLCPPDRT GSHCQEVTRK PCSVNGHVTP DGVKWDEDCN TCHCSNGKVV CTKMWCGPMS
CKLGAKGRGE CPSGQSCIPL REGHCFVKPC IELGECWHSD PPQPPTKCHP SSTYQDNSCA
NITFTFNKEI MPRGLTVEGV CKQLRSLYVV KNFSLEHSVS ITCDPSFSAS NEIHVCISTD
DHRLDGSPVK KITERIIDLV SKHNGNNTII SAIAEVRVPS PSKTDYLVPL LSSIFIVIWV
LVLVSILLWC MRRRRKQSNH NGTSATSSED NTTNNVREQL NQIKNPIEKH VGLTVAIKDY
ENKNSIIAKI RTNHPEGDED DKERHLQKGR FAKQPAYTLV ERDEKATISN PNSTSKHANW
TNKQDNRDLE TANSINRMDY IV
//
