ID   A0A3B4GV06_9CICH        Unreviewed;       904 AA.
AC   A0A3B4GV06;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO5 {ECO:0000313|Ensembl:ENSPNYP00000026014.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000026014.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000026014.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A3B4GV06; -.
DR   Ensembl; ENSPNYT00000026650.1; ENSPNYP00000026014.1; ENSPNYG00000019586.1.
DR   GeneTree; ENSGT00940000155692; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF23; ANOCTAMIN-5; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          49..266
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          269..856
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   904 AA;  106431 MW;  4167B10772467D04 CRC64;
     MLLNFVLNRF VRLSLTVHSV PPQFSRKRAL FLKFRSRIDK QKYSKDSVFF RDGVRRIDFV
     LSYIDDKDDQ RKQERRRVYE SNLQKVGLEL ETEDKTESED GKTYFVKIHA PWEVLATYAD
     VLKIKVPFKV NDIPDNSEIP MNWLSTPFRL PGHIMNPEPD YFTAPFNKSK SDFFLIEDKE
     TFFPPSTRNR IVYYILARCP YFKDECGDRD KKGIKRLLNN GTYTAAFPLH DSRYWTKSKD
     PNCESERFSL YKYWAKFFCF FKEQPLNLVR KYYGEKIGIY FAWLGFYTEM LFFAAVVGTI
     CFVYGFLTYD DNEWSKEICS EEIGGNIVMC PLCDQKCTYW RLNITCNSSW QSHLFDNVAT
     VFFAIFMGIW VTLFLEFWKR RQARLEYEWD LVDFEEEQQQ LQLRPEYETK CTNRKLNRIT
     QESEWVLERT ATDVMGKLFL CWASVILWIS LIIACIIGVI AYRLAVYASF ASIMKNNTAT
     NLDVVAPYVT PQLATSVTAS CINFVIIMIL NLLYERVAIK ITDMEIPKTH VEYENKLTVK
     MFLFQFVNYY SSCFYVAFFK GKFVGYPGNY TYMFGSSKLR NEECEPGGCL IELTTQLVIV
     MTGKQVWGNI QEALVPWLMN WWGSRKARSH PESLYSRWEQ DYDLQGFGQL GLFYEYLEMV
     IQFGFITLFV ASFPLAPLLA LINNIIEVRV DAWKLTTQFR RPVAAKAHSI GAWEEILGGV
     AVLSVVTNAF IVAFTSDMIP RLVYMYAYRT HDELNMKGYI NNSLSVFNIS QFSLEERPEE
     YPSWFNSSIT TCRYRDYRYP PDDKKRYEHN MQFWHILAAK LAFIIIMEHV VFMVKFFVAW
     MIPDVPSDVR ARVKRERYLV QEYLHNYEVE KLKIQLSQNS NNDCTCTPMI YPSLSKHEVL
     SECL
//