ID A0A3B4GYB0_9CICH Unreviewed; 335 AA.
AC A0A3B4GYB0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Protein NDRG2 {ECO:0000256|ARBA:ARBA00015427, ECO:0000256|RuleBase:RU367129};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000027174.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000027174.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC Down-regulates CTNNB1-mediated transcriptional activation of target
CC genes. May be involved in neuron differentiation.
CC {ECO:0000256|RuleBase:RU367129}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU367129}.
CC -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000256|ARBA:ARBA00005598,
CC ECO:0000256|RuleBase:RU367129}.
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DR AlphaFoldDB; A0A3B4GYB0; -.
DR STRING; 303518.ENSPNYP00000027174; -.
DR Ensembl; ENSPNYT00000027835.1; ENSPNYP00000027174.1; ENSPNYG00000020432.1.
DR GeneTree; ENSGT00950000182872; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-UniRule.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR PANTHER; PTHR11034:SF17; PROTEIN NDRG2; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367129};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367129};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|RuleBase:RU367129};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW ECO:0000256|RuleBase:RU367129};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU367129}.
FT REGION 297..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 36926 MW; 423C291F3AD20A72 CRC64;
LVETPHGVLH VTLHGTRTTR RPAILTFHDV GLDSKSCFSP LFKFEEMQEI VKNFTLIHID
APGQEEGAAA YPAGYQYPSM ETISEMIPAV LQFFNFRTVI GVGVGAGAYI LARFALTNPD
AVEGLVLINI DTNARGWIDW AAQKLSSVTS SLTEQILCHL FSQEELSSST DLVQSYRERI
SKAPNLSNME LLWKSYNSRR DLIFDRNSAF NTCFCLTLRC PVMLVVGDHA PYEDAAVECN
SKMDPTTTSF LKMADAGGLP QLTQPAKLTE AFKYFIQGMG YMASSCMTRL SRSRTTSLSS
SYSMDGSRSR SRTLSQGSQG GQMPPSPSQT MEVSC
//
