ID   A0A3B4H167_9CICH        Unreviewed;       717 AA.
AC   A0A3B4H167;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Leucine rich repeat neuronal 1 {ECO:0008006|Google:ProtNLM};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000028209.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000028209.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4H167; -.
DR   STRING; 303518.ENSPNYP00000028209; -.
DR   Ensembl; ENSPNYT00000028899.1; ENSPNYP00000028209.1; ENSPNYG00000021244.1.
DR   GeneTree; ENSGT00940000157154; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 1.
DR   CDD; cd00096; Ig; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR24373:SF97; LEUCINE-RICH REPEAT NEURONAL PROTEIN 1; 1.
DR   PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00365; LRR_SD22; 4.
DR   SMART; SM00369; LRR_TYP; 9.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..717
FT                   /note="Leucine rich repeat neuronal 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017325387"
FT   TRANSMEM        631..654
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          425..516
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          526..618
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          693..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  81479 MW;  9633D2B45F4A97B9 CRC64;
     RVISNRFSPW PPLIWLCIGL LLCFLSPAHG KDCPHLCVCE IRPWFTPQST YKEATTVDCN
     DLRLTHIPTN LSVDTQVLLL QSNAISRTSG ELEVLFNLTE LDLSQNNFST VEAVGLTSMN
     HLTTLHLEEN QITQLPDHCL QNLSNLQELY INHNQISSIS PRAFAGLHSL LRLHLNSNRL
     HVIDSRWFEE TPNLEILMIG ENPVIGLLDM NFKPLVRLRS LVLAGMDLTD VPPDAFVGLD
     NLESISFYDN KLVSIPQLAL QKVPNLKFLD LNKNPVQKIQ EGDFRNMLRL KELGINNMME
     LVSIDRYAMD NLPELTKLEA TNNPKLSYIH RFAFRDMPSL ESLMLNNNAL TALYKQTVDV
     LPNLREISLH SNPLRCDCVI QWMNSNRTTV RFMEPLTMLC TSPPEFRGQR VREFRLLEST
     EQCLPLISHE TFPSHLNLEL GMSVSLDCRA MAEPNPDIYW VTPLGNKITM DTVSERYHLS
     SEGTLRLSHV QVQDSGRYTC VAQNTEGADT RVATIRINGT LLDSAQVMKI YVKQTESHSI
     LVSWKVNSNV MSSNLKWASA TMKIDNPHIT YTARVPVDVH EYNLTHLQPA TEYEVCLTVS
     NIHLQTHKSC VNVTTRSATF ALDLTDQHPS AAVLAVMSTM LLFLSLATVG IYMARRWKRK
     NYHHSLKKYM LKTSSIPLNE LYPPLINLWE ADGEKDKDGS TEGKPSPVDT TRSYYMW
//