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Database: UniProt
Entry: A0A3B4H2J4_9CICH
LinkDB: A0A3B4H2J4_9CICH
Original site: A0A3B4H2J4_9CICH 
ID   A0A3B4H2J4_9CICH        Unreviewed;      1174 AA.
AC   A0A3B4H2J4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=FYVE, RhoGEF and PH domain containing 6 {ECO:0000313|Ensembl:ENSPNYP00000028684.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000028684.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000028684.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
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DR   AlphaFoldDB; A0A3B4H2J4; -.
DR   STRING; 303518.ENSPNYP00000028684; -.
DR   Ensembl; ENSPNYT00000029382.1; ENSPNYP00000028684.1; ENSPNYG00000021583.1.
DR   GeneTree; ENSGT00940000156334; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd15743; FYVE_FGD6; 1.
DR   CDD; cd13237; PH2_FGD5_FGD6; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF12; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00064; FYVE; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          627..816
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          845..939
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          975..1034
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   DOMAIN          1075..1171
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..207
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..257
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..291
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..398
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..427
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1174 AA;  131808 MW;  2E730E62D0044DDA CRC64;
     VTTKPSPPPV APKPGLICQP LAVSQPSPST LKRAKPAVAP KPCIPKYSVQ EAFDDGLNLL
     NSKNGILSEA SRRESDYIIP TCSCGLRDCA QCQPLENGST SEAGGHSHKE LLENGVSKEG
     FVGSNKEVQR TKEQEVTLKN QESPAAELDV SKVSTEAQNT HLKSACDVIG GIIVFSSISP
     LELPTEYSES SNTVSRVSPT QSHPDLQVPA APSKPLPVPQ PRKLKKPALV RQDGLEGGAQ
     EQFVEEQKQR TEMKEAEGKL AALSLSTESE ELKPDACDDS SPPKDSGLGD DEADAPVPPP
     RQTSLSPHLH RSFRINPNLN KNNSHSLDLL SQPDSVSHSK EGEARRAEED EEDGYGDFER
     YPISHSLPKQ IKLSCHPPLA NDRKAFSAEE EQSPRAPPRK PQRHSLPAPP PPSICPPAPP
     HANTPMRELP APPQEKTSWR FSRPYVTFFS RQIPTRSSVP PKSRAPVLGC KQRAQSFSAA
     DLATRANSPK RSLSFRKLLE LRLSVKMLPK LLAKGGQSLD CTSVESNRGK RSLERPSSCI
     GEADICGEGI EGLAEYENVP LYEEIPEYMN LPFHSARLGW PHDPDAADAD IYEVQDPYHR
     CQEHEYERYA ALLINFFSQE DEMKRKKVVH IAQEIMSSEK VFVDVLKLLH IDFRDAVAKA
     TRQNGKPVVD ERILCQILYY LPQLYQLNKD LLRELEERVA HWSDHQRLSD IFVQKGPYLK
     MYSTYIRQFD NNVALLDEQC RKNPAFAAVV REFEMSPRCA SLALKHYLLK PVQRIPQYQL
     LLTDYLKNLP EDSEDYKDTQ AALSIVKEVA NHANDIMKQG DNFQKLMQIQ YSLTGHHEIV
     QPGRVFLKEG TLMKLSRKVM QPRMFFLFND ALMYTTPVQS AQYKLNSVLS LAGMKVSKPS
     QEAYQNELNI ESVERSFILS ASSATERDEW LEAIAKAIDD YTKKKITFIS SRSQEEGVVD
     SGAPLGSKAP IWIPDLRATM CMICTCEFTL TWRRHHCRAC GKVVCQACSA NKYYLEYLKN
     QPARVCDHCF AKLQENSDRC ASTSISPIKS GAFSFTRKQK KIPAALKEVS ANTENSSMSG
     YLNRSKGNKK QWKRLWFVIK NKVLYTYAAS EDVAALESQP LLGFFLREEK NGPAQKLQFK
     LYHKNTLFYI FKADDIPTAQ RWIEAFQEAM ILEQ
//
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