ID A0A3B4H379_9CICH Unreviewed; 1067 AA.
AC A0A3B4H379;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=SLIT-ROBO Rho GTPase activating protein 1 {ECO:0000313|Ensembl:ENSPNYP00000028028.1};
GN Name=SRGAP1 {ECO:0000313|Ensembl:ENSPNYP00000028028.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000028028.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000028028.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4H379; -.
DR STRING; 303518.ENSPNYP00000028028; -.
DR Ensembl; ENSPNYT00000028714.1; ENSPNYP00000028028.1; ENSPNYG00000021071.1.
DR GeneTree; ENSGT00950000182824; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR CDD; cd11955; SH3_srGAP1-3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035648; srGAP1/2/3_SH3.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR14166:SF15; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 21..312
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 471..665
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 714..773
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 781..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..804
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 121742 MW; 7A236F3940C6B6D3 CRC64;
FSSITRSQKA KTSVYEYQPH ICIRAQLVEQ QKCLDQQTEM RVQLLQDLQD FFRKKAEIEM
EYSRNLEKLA ERFMAKTRST KDHQQYKKDQ NLLSPVNCWY LLLNQVRRES KDHATLSDIY
LNNVIMRFMQ ISEDSTRLLK KSKEIAFQLQ EDLMKVLNEL YTVMKTYHMY HSESISAESK
LKEAEKQEEK QIGRADPVFS IRMEEKYQRR SSVKKIEKMK EKRQAKYSEN KLKSIKARNE
YLLTLEATNS SVYKYYIHDL SDLIDCCDLG YHASLNRALR TYLSAEYNLE TSRHEGLDII
ENAVDSLDPR SDRQRFMEMY PTAFCPPAKF EFQPHMGDEV CQISVQPPVN GELILRFQQL
QSRIATLKIE NEEIKKTSEA TLTTIQDMVT IEDYDVSECF HHSRSTESVK STVSETYLSK
PSIAKRRANQ QETEQFYFMK FREFLEGSNL ISKLQAKHDL LKRALGEGTF RTLRGRRNSH
TRHQDSGQAI PRVVESCIRY INLYGLQHQG IFRVPGSQLE VNDIKNSFER GNDPLADDEN
NHDINSVAGV LKLYFRGLEN PLFPKERFNE LLSCIRIENL YERALYIRKI LLTIPRSVLI
VMRYLFAFLN HLSQYSDENM MDPYNLAICF GPTLMPTPDS QDQVSCQAHV NEIIKTIIIH
HETIFPDVKE LDGPIYEKCM AGGDYCESPY SEHGALEEVD NEGGTETHTS EDEGEPIEAI
AKFDYVGRSS RELSFKKGAS LLLYQRASED WWEGRHNGID GLVPHQYIVV QDIDDNFSDT
LSQKADSEAS SGHAGEDKCS GKDIGSPNDT RISEAFITRK RSDPPSRRPP ARPSDVHCMV
HTSQQSHSGH GGTPEMGSPV LGHFSPRDML RSRNHVAIDS PERRRRAGHS SLTNISRHES
LKKMESPPIR RSTSSGQYTG FTDPLDPETI AQDIEETMNT ALNELRELER QSSAKHAPDV
VLDTLEQRQT SGSSGGGPTP ASSSESLSPI HAVMLRSTAN TEPPTRRSTS SSNDSVSTFK
PVVAPRMGVQ LKPPALRPKP MVLPKSNQAP QPPANSSQDP LDKSCTM
//
