ID A0A3B4H6B8_9CICH Unreviewed; 1942 AA.
AC A0A3B4H6B8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN8A {ECO:0000313|Ensembl:ENSPNYP00000028946.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000028946.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000028946.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 303518.ENSPNYP00000028946; -.
DR Ensembl; ENSPNYT00000029654.1; ENSPNYP00000028946.1; ENSPNYG00000021794.1.
DR GeneTree; ENSGT00940000156263; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008054; Na_channel_a8su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF23; SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01667; NACHANNEL8.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 199..218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 230..251
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 351..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 390..417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 721..745
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 757..775
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 836..865
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 924..950
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1173..1191
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1212..1231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1243..1263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1289..1315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1412..1434
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1482..1500
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1512..1530
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1542..1562
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1599..1627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1702..1725
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 139..424
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 545..675
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 726..956
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 964..1166
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1171..1435
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1481..1735
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 26..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1886..1942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1886..1908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1910..1942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1942 AA; 221246 MW; 196341E874AA9772 CRC64;
MAAPLLAPPG PDSFRKFTPE SLVVLEQRIQ EEKNKKPPKQ DSSYRDDDDE NKPKPNSDLE
AGKSLPYIYG DIPKGMAAVP LEDLDPFYVN SQKTFIVLNR GKTIFRFSAT PALYLISPFN
PVRRLAIKIL IHSYPLKCMI IMCTILTNCI FMTFSDPPEW SKQVEYTFTG IYTFESLVKI
TARGFCIDGF TFLRDPWNWL DFMVISMAYI TEFVNLGNVS ALRTFRVLRA LKTISVIPGL
KTIVGALIQS VKKLSDVMIL TVFCLSVFAL IGLQLFMGNL RHKCVFWPIN TNESYLANGS
KGFDWDEYIT NDTNFYFLPG QLDALLCGNS SDSGRCPEGY TCMKAGRNPN YGYTSFDSFG
WAFLALFRLM TQDFWENLYM LTLRAAGKTY MIFFVLVIFV GSFYLVNLIL AVVAMAYEEQ
NQATMEEAAQ KEEEFKAMLE QLKKQQEDAQ TAAMATSAGT VSEDAVEDDG GGRLSCSSSE
MSKLSSKSAK ERRNRKKKWR QKEQEKEKGD SEKFVKSESD DGSKRSRFRF PDNRLGRKSS
IMNQSLLSIP GSPFLSRHNS KSSIFSFKGR SKDVGSENEF ADDEHSTVEE CEERRGSLFS
PYRRSSYTGF HGKRNSTVDC NGVVSLIGPG PGGRLLPEPT TEVEVKKKLS GSLMVSVDQL
NTSFGRKERA NSVMSVITNT LVEELEESQR KCPPCWYKFA NTFLIWECSP KWIKIKEIVN
LIVMDPFVDL AITICIVLNT LFMAMEHYPM TPDFEDMLSV GNLVFTGIFA GEMLFKLVAM
DPYYYFQEAW NCFDGFIVTL SLVELALADV EGLSVLRSFR LLRVFKLAKS WPTLNMLIKI
IGNSVGALGN LTLVLAIIVF IFAVVGMQLF GKNYKDCVCK ISAECELPRW HMNDFFHSFL
IVFRVLCGEW IETMWDCMEV AGQAMCLIVF MMVMVIGNLV VLNLFLALLL SSFSADNLAA
TDDDGEPNNL QISVMRIKKG IAWIKAKMRL LMASLLRKPP MEDEQKPLED MYDKKLNCIA
NHTGVDINRD LDYAKNGNGT TSGIGSSVGK YMIDEDHMSF IHNPNLTVCV PIAVGESDFE
NLNTEDFSSE SDNENSKELD DTSSSEGSTI DIKPDVEEVV VVETVEEYME PESCWTDACV
AKYKCCDVDI TMGWGKSWWF LRKTCYLIVE HNWFETLIIF MILLSSGALA FEDVYIEQRK
TIRIILEYAD RVFTYIFILE MLLKWVAYGF VKYFTNAWCW LDFFIVDVSI VSLVANALGY
SDLGPIKSLR TLRALRPLRA LSRFEGMRVV VNALVGAIPS IMNVLLVCLI FWLIFSIMGV
NLFAGKYYYC FNETSEEYFP TSVVDNKTQC FEFINQNYSE VRWKNVKINF DNVGAGYLAL
LQVATFKGWM DIMYAAVDSR EVEKQPDYEV NIYMYIYFVV FIIFGSFFTL NLFIGQDIFM
TEEQKKYYNA MKKLGSKKPQ KPIPRPQNKI QGMVFDFVTQ QVFDISIMIL ICLNMVTMMV
ETDDQSDETE IVLYWVNFIF IVIFTTEFLL KLFALRHYYF TNGWNIFDVV VVILSIVGMF
LADLIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL FNIGLLLFLV
MFIFSIFGMS NFGYVKHGAG IDDLYNFETF GNSMIILFMI TTSAGWDGLL LPILNYPPDC
DPNLENPGTS VKGDCGNPSV GIFFFVMYII ISFLIVVNMY IAIILENFSV ATEESADPLS
EDDFETFYEI WEKFDPTASQ FISFAKLPDF ADALEHPLRV PKPNTIELIA MDMPMVSGDR
IHCLDILFAF TKRVLGDSGE LDMLRQQMEE RFVAANPSKV SYEPITTTLR RKQEDVSART
IQNAYRAHLI RRGIIFKRIF ANNKLENGGT NQEKKESTPS TASLPSYDSV TKPEKEKQDD
NKEEWARKEK DKNQKDEWES KC
//
